Results 31 to 40 of about 1,052,124 (265)

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

The Low-mass Stellar Initial Mass Function in Nearby Ultrafaint Dwarf Galaxies

The Astrophysical Journal
The stellar initial mass function (IMF) describes the distribution of stellar masses that form in a given star formation event. The long main-sequence lifetimes of low-mass stars mean that the IMF in this regime (below ∼ 1 M _⊙ ) can be investigated ...
Carrie Filion, Rosemary F. G. Wyse, Hannah Richstein, Nitya Kallivayalil, Roeland P. van der Marel, Elena Sacchi   +5 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Constraining the z ∼ 1 Initial Mass Function with HST and JWST Lensed Stars in MACS J0416.1−2403

The Astrophysical Journal
Our understanding of galaxy properties and evolution is contingent on knowing the initial mass function (IMF), and yet to date the IMF is constrained only to local galaxies.
Sung Kei Li, Jose M. Diego, Ashish K. Meena, Jeremy Lim, Leo W. H. Fung, Arsen Levitskiy, James Nianias, Jose M. Palencia, Hayley Williams, Jiashuo Zhang, Alfred Amruth, Thomas J. Broadhurst, WenLei Chen, Alexei V. Filippenko, Patrick L. Kelly, Anton M. Koekemoer, Derek Perera, Bangzheng Sun, Liliya L. R. Williams, Rogier A. Windhorst, Haojin Yan, Adi Zitrin   +21 more
doaj   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Why is the Star Formation Rate Proportional to Dense Gas Mass?

The Astrophysical Journal
One of the most profound empirical laws of star formation is the Gao–Solomon relation, a linear correlation between the star formation rate (SFR) and the dense molecular gas mass.
Sihan Jiao, Fengwei Xu, Hauyu Baobab Liu, Yuxin Lin, Jingwen Wu, Zhi-Yu Zhang, Zhiqiang Yan, Di Li, Chao-Wei Tsai, Yongkun Zhang, Linjing Feng, Ke Wang, Zheng Zheng, Fanyi Meng, Hao Ruan, Fangyuan Deng, Keyun Su   +16 more
doaj   +1 more source

Comparison of physical characteristics of mass and luminosity function of disk systems in barred and unbarred spiral galaxies

مجلة بغداد للعلوم
Among the most important ways to investigate galaxies' distribution over cosmic time is the luminosity function LF in terms of baryonic disc mass ψS(Mb), magnitude  .
Al Najm M.N., Y. E. Rashed , H. H. AL-Dahlaki   +2 more
doaj   +1 more source

The Earliest Stage of Galactic Star Formation

The Astrophysical Journal Letters, 2023
Using a recently developed technique to estimate gas temperatures ( T _SF ) in star-forming regions from large photometric surveys, we propose a diagram, analogous to the Hertzsprung–Russell diagram for individual stars, to probe the evolution of ...
Charles L. Steinhardt, Vadim Rusakov, Thomas H. Clark, Andrei Diaconu, John Forbes, Conor McPartland, Albert Sneppen, John Weaver   +7 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source