Results 71 to 80 of about 7,371 (263)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Autonomous Orbit Determination of LLO Satellite Using DRO–LLO Links and Lunar Laser Ranging

Aerospace
A stable and high-precision autonomous orbit determination scheme for a Low Lunar Orbit (LLO) spacecraft is proposed, leveraging satellite-to-satellite tracking (SST) measurement data and lunar laser ranging data.
Shixu Chen, Shuanglin Li, Jinghui Pu, Yingjie Xu, Wenbin Wang   +4 more
doaj   +1 more source

Method of preliminary solution of the problem of space robot navigation by onboard astronomical measurements using the butterworth filter

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2020
A method of preliminary solution of the problem of space robot navigation based on the results of measurements carried out using its onboard optronic equipment is presented.
V. M. Ananenko, A. D. Golyakov, P. V. Kalabin   +2 more
doaj   +1 more source

Initial orbit determination with the multibeam radar sensor BIRALES

Acta Astronautica, 2020
Abstract In this work we present a conceptual analysis of the use of the novel Italian multibeam radar sensor BIRALES for space surveillance. The dedicated orbit determination algorithm is described in detail. The algorithm is tailored to the peculiar configuration of the receiver gain pattern and is devoted to both reconstructing the track of the ...
Matteo Losacco, Pierluigi Di Lizia, Mauro Massari, Giovanni Naldi, Giuseppe Pupillo, Germano Bianchi, Jan Siminski   +6 more
openaire   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Probabilistic Initial Orbit Determination

, 2016
Future space surveillance requires dealing with uncertainties directly in the initial orbit determination phase. We propose an approach based on Taylor differential algebra to both solve the initial orbit determination (IOD) problem and to map uncertainties from the observables space into the orbital elements space. This is achieved by approximating in
ARMELLIN, ROBERTO, DI LIZIA, PIERLUIGI
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Initial Values Determination of Thrust Parameters for Continuously Low-Thrust Maneuvering Spacecraft

Applied Sciences
Continuous low thrust is widely used in orbit transfer maneuvers. If the unknown maneuvers are not correctly compensated, the orbiting accuracy will be seriously affected.
Wen Guo, Xuefeng Tao, Min Hu, Wen Xue
doaj   +1 more source

A Method to Determine BeiDou GEO/IGSO Orbital Maneuver Time Periods

Sensors, 2019
Because there are different types of BeiDou constellations with participating geostationary orbit (GEO) and inclined geosynchronous orbit (IGSO) satellites, the maneuvering frequency of BeiDou satellites is higher than that of other navigation systems ...
Zhiwei Qin, Guanwen Huang, Qin Zhang, Le Wang, Xingyuan Yan, Yanchao Kang, Xiaolei Wang, Shichao Xie   +7 more
doaj   +1 more source