Results 41 to 50 of about 3,499,923 (363)

L’adoption de l’approche par compétence par les enseignants

open access: yesThe Journal of Quality in Education, 2019
L’approche par compétence « APC » est considérée comme l’une des approches pédagogiques les plus appropriées pour un apprentissage efficace. Cependant, bien qu’elle soit de plus en plus recommandée par le système éducatif marocain, on constate une ...
ABDELALI ARBIA   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Les plans de formation des magistrats et agents des finances publiques sont-ils des actes de langage ou des décisions politiques ?

open access: yesRevue Française des Sciences de l’Information et de la Communication, 2017
Is the training of magistrates and tax agents intended to make them more effective in fighting financial crime or is the goal more in line with the rationale of harmonising behaviours ?
Frédéric Compin
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Concevoir une séquence d’enseignement-apprentissage de l’adjectif : pièges et difficultés en formation initiale

open access: yesLidil
Our contribution analyses the traces of students undergoing initial teacher training for primary teaching. In writings on the preparation of sequences on the adjective and extracts from their research dissertations, we observe how novice teachers deal ...
Annette Schmehl-Postaï
doaj   +1 more source

Knowledge and Influence of MOOC Courses on Initial Teacher Training

open access: yes, 2015
The impact of MOOC courses in the processes of distance learning has been extremely important from the very beginning. They offer an innovative model of massive teaching, which exploits in a paradigmatic manner the potential and relevance that ICT's ...
Gomez-Galan, Jose, Perez-Parras, Jessica
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Gender perspective: perceptions by pre-school education program students of a Chilean regional university

open access: yesFrontiers in Education
The aim of this study was to analyze perceptions on gender, sexist practices and stereotypes by Pre-School Education program students in the context of pre-school classrooms. To this end, we carried out a mixed method interpretative research based on the
Lilian Narváez-Prosser   +5 more
doaj   +1 more source

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