Results 51 to 60 of about 1,052,374 (268)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Les plans de formation des magistrats et agents des finances publiques sont-ils des actes de langage ou des décisions politiques ?

Revue Française des Sciences de l’Information et de la Communication, 2017
Is the training of magistrates and tax agents intended to make them more effective in fighting financial crime or is the goal more in line with the rationale of harmonising behaviours ?
Frédéric Compin
doaj   +1 more source

TRAIN: Training through Research Application Italian Initiative

The International Journal of Biological Markers, 2011
Training through Research Application Italian iNitiative (TRAIN) is a mobility program financed under the EU action called “Cofinancing of regional, national and international programs” (COFUND) of the European Commission Seventh Framework Program (FP7) – People, and has been designed to encourage the promotion and development of international programs
C. Lombardo, S. Bottero, F. d'Alessandro, GIACOMINI, MAURO, A. Guaderzo, F. Moretti, M. Marincola, G. Pesce, M. A. Pierotti, L. G. Spagnoli, F. Belardelli   +10 more
openaire   +5 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Trainers’ Perceptions of Initial Physical Education Teacher Training within Moroccan CRMEFs: Preliminary Development and Exploratory Validation of an Evaluation Grid

Physical Education Theory and Methodology
Objectives. This study aimed to examine teacher trainers’ perceptions of initial Physical Education and Sport teacher training within Moroccan Regional Centers for Education and Training Professions and to provide preliminary evidence of the exploratory
Hamza Marzak, Mouhcine El Qryefy, Hanan El Faylali, Youssef El Madhi   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Gender perspective: perceptions by pre-school education program students of a Chilean regional university

Frontiers in Education
The aim of this study was to analyze perceptions on gender, sexist practices and stereotypes by Pre-School Education program students in the context of pre-school classrooms. To this end, we carried out a mixed method interpretative research based on the
Lilian Narváez-Prosser, Gloria Sanzana-Vallejos, Angélica Corrales-Huenul, Valentina Soto-Hernández, José Luis Garcés-Bustamante, Yasna Patricia Ferrada-Montecinos   +5 more
doaj   +1 more source

Impact of Mentoring Functions on Career Development: Moderating Role of Mentoring Culture and Mentoring StructureImpact of Mentoring Functions on Career Development: Moderating Role of Mentoring Culture and Mentoring Structure [PDF]

Ovidius University Annals: Economic Sciences Series, 2020
Facilitating the development of students' professional skills for the professional insertion in the education system, by reducing the gaps between educational theory and the concrete realities of practice school.
Anca-Elena Aviana, Florica Rotaru, Alina Șerban   +2 more
doaj  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source