Results 41 to 50 of about 3,997,941 (282)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Global extrapolation procedures for special and general initial value problems [PDF]

, 1986
Two- and three- grid global extrapolation procedures are considered fohe special and general initial value problems of arbitrary order r tq. Extrapolation formulas are developed for consistent numerical methods of arbitrary order p .
Khaliq, AQM, Twizell, EH
core   +1 more source

Time-Fractional Optimal Control of Initial Value Problems on Time Scales

, 2019
We investigate Optimal Control Problems (OCP) for fractional systems involving fractional-time derivatives on time scales. The fractional-time derivatives and integrals are considered, on time scales, in the Riemann--Liouville sense.
A Ahmadkhanlu, A Cabada, AB Malinowska, B Bayour, Benaoumeur Bayour, Benaoumeur Bayour, D Baleanu, D Baleanu, D Idczak, D Mozyrska, E Hernández, EG Bajlekova, ER Nwaeze, G Mophou, GM Bahaa, GM Mophou, GSF Frederico, GSF Frederico, I Podlubny, K Mekhalfi, L Bourdin, M Bohner, M Bohner, MC Caputo, Monika Dryl, Moulay Rchid Sidi Ammi, Moulay Rchid Sidi Ammi, N Benkhettou, N Benkhettou, N Benkhettou, N Benkhettou, N Özdemir, NRO Bastos, NRO Bastos, NRO Bastos, O Lavrova, OP Agrawal, OP Agrawal, R Almeida, RP Agarwal, RP Agarwal, S Abbas, T Abdeljawad, Thabet Abdeljawad   +43 more
core   +1 more source

Initial-boundary value problems for continuity equations with BV coefficients [PDF]

, 2013
We establish well-posedness of initial-boundary value problems for continuity equations with BV (bounded total variation) coefficients. We do not prescribe any condition on the orientation of the coefficients at the boundary of the domain.
Crippa, Gianluca, Donadello, Carlotta, Spinolo, Laura V.   +2 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Efficient Semi-Analytic Technique for Solving Nonlinear Singular Initial Value Problems

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
 The aim of this paper is to present a semi - analytic technique for solving singular initial value problems of ordinary differential equations with a singularity of different kinds to construct polynomial solution using two point  osculatory ...
Luma N. M. Tawfiq, Reem W. Hussein
doaj  

Solution of infinite horizon nonlinear optimal control problems by piecewise adomian decomposition method

Mathematical Modelling and Analysis, 2013
In this paper, a Piecewise Adomian Decomposition Method (PADM) is used to obtain the analytical approximate solution for a class of infinite horizon nonlinear optimal control problems (OCPs). The method is a new modification of the standard ADM, in which
Hassan Saberi Nik, Paulo Rebelo, Moosarreza Shamsyeh Zahedi   +2 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

On Solution of Regular Singular Initial Value Problems

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
    This paper devoted to the analysis of regular singular initial value problems for ordinary differential equations with a singularity of the first kind , we propose semi - analytic technique using two point osculatory interpolation to construct ...
Luma. N. M. Tawfiq, Reem. W. Hussein
doaj  

Review of Summation-by-parts schemes for initial-boundary-value problems

, 2013
High-order finite difference methods are efficient, easy to program, scales well in multiple dimensions and can be modified locally for various reasons (such as shock treatment for example).
Nordström, Jan, Svärd, Magnus
core   +1 more source