Mechanistic studies of initiator-initiator interaction and replication initiation [PDF]
The EMBO Journal, 1998 Unlike the chromosome of Escherichia coli that needs only one replication initiator protein (origin recognition protein) called DnaA, many plasmid replicons require dual initiators: host-encoded DnaA and a plasmid-encoded origin recognition protein, which is believed to be the major determinant of replication control. Hitherto, the relative mechanistic
Y B, Lu, H J, Datta, D, Bastia
openaire +2 more sources
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. [PDF]
, 2013 The initiation of protein synthesis plays an essential regulatory role in human biology. At the center of the initiation pathway, the 13-subunit eukaryotic translation initiation factor 3 (eIF3) controls access of other initiation factors and mRNA to the
Arias-Palomo, Ernesto +6 more
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Structural visualization of key steps in human transcription initiation. [PDF]
, 2013 Eukaryotic transcription initiation requires the assembly of general transcription factors into a pre-initiation complex that ensures the accurate loading of RNA polymerase II (Pol II) at the transcription start site. The molecular mechanism and function
Fang, Jie +3 more
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Initiation of hydrogen induced cracks at secondary phase particles [PDF]
, 2020 The goal of this work is to propose a general mechanism for hydrogen induced crack initiation in steels based on a microstructural study of multiple steel grades.
Claeys, Lisa +5 more
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A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing
Nature Communications, 2021 CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may confer
Sanju Sinha +12 more
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Determinants of timely initiation of breastfeeding among mothers in Goba Woreda, South East Ethiopia : a cross sectional study [PDF]
, 2011 Background: Although breastfeeding is universal in Ethiopia, ranges of regional differences in timely initiation of breastfeeding have been documented. Initiation of breastfeeding is highly bound to cultural factors that may either enhance or inhibit the
Setegn, Tesfaye +2 more
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Frontiers in Oncology, 2018 The importance of epigenetic dysregulation to acute myeloid leukemia (AML) pathophysiology has become increasingly apparent in recent years. Epigenetic regulators, including readers, writers, and erasers, are recurrently dysregulated by way of ...
Younguk Sun +2 more
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Memories and history of Hansen's disease in Brazil told by witnesses (1960-2000) [PDF]
História, Ciências, Saúde: Manguinhos, 2003 This report is a preliminary result of a survey on memories and history of Hansen's disease, or 'hanseniasis', prepared by the Fundação Oswaldo Cruz (Fiocruz) and the Universidade Federal do Rio de Janeiro (UFRJ) using statements from those who have been
Laurinda Rosa Maciel +3 more
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The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs. [PDF]
, 2018 The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian orthologue DDX3 are critical for the initiation of translation1.
Bartel, David P +10 more
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Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models
Cells, 2021 Chordomas are rare, slow-growing tumors of the axial skeleton. These tumors are locally aggressive and refractory to conventional therapies. Radical surgery and radiation remain the first-line treatments.
Marie-Anaïs Locquet +13 more
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