Results 41 to 50 of about 3,819,967 (357)

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance.

Cell Stem Cell, 2019
Our traditional understanding of phenotypic plasticity in adult somatic cells comprises dedifferentiation and transdifferentiation in the context of tissue regeneration or wound healing. Although dedifferentiation is central to tissue repair and stemness,
Piyush B. Gupta, I. Pastushenko, Adam Skibinski, Cédric Blanpain, Charlotte Kuperwasser   +4 more
semanticscholar   +1 more source

Crack Growth Behavior through Wall Pipes under Impact Load and Hygrothremal Environment

Al-Khawarizmi Engineering Journal, 2018
This research concerns study the crack growth in the wall of pipes made of low carbon steel under the impact load and using the effect of hygrothermal (rate of moisture 50% and 50℃ temperature).
Ali Jamal Khaled, Ahmed Abdul Hussain
doaj   +1 more source

Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation

Frontiers in Microbiology, 2021
Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA.
Elena M. Maksimova, Daria S. Vinogradova, Daria S. Vinogradova, Ilya A. Osterman, Ilya A. Osterman, Pavel S. Kasatsky, Oleg S. Nikonov, Pohl Milón, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova, Petr V. Sergiev, Petr V. Sergiev, Petr V. Sergiev, Petr V. Sergiev, Alena Paleskava, Andrey L. Konevega, Andrey L. Konevega   +18 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

Nature Communications, 2019
Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this ...
Catherine Lee, Vasilisa A. Rudneva, Serap Erkek, Marc Zapatka, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Alexandra Garancher, Jessica M. Rusert, Ozlem Aksoy, Robin Lea, Helai P. Mohammad, Jianxun Wang, William A. Weiss, H. Leighton Grimes, Stefan M. Pfister, Paul A. Northcott, Robert J. Wechsler-Reya   +16 more
doaj   +1 more source

Reviewing progress: 7 Year Trends in Characteristics of Adults and Children Enrolled at HIV Care and Treatment Clinics in the United Republic of Tanzania. [PDF]

, 2013
To evaluate the on-going scale-up of HIV programs, we assessed trends in patient characteristics at enrolment and ART initiation over 7 years of implementation. Data were from Optimal Models, a prospective open cohort study of HIV-infected (HIV+) adults (
A Anema, AA Ahonkhai, Ahmed Khatib, AN Kiragga, Annette Almeida, BH Lambdin, Bonita Kilama, C Gwynn, C Hawkins, C Kouanfack, C Tayla, EH Geng, Elaine J Abrams, G Somi, Gongo Ramadhani, Gretchen Antelman, H Nuwagaba-Biribonwoha, H Nuwagaba-Biribonwoha, Harriet Nuwagaba-Biribonwoha, ICAP, Columbia University, J Birungi, J Wachira, Joint United Nations Programme on HIV/AIDS (UNAIDS), K Koo, K Peltzer, M Lahuerta, M Lahuerta, M Lahuerta, M Reece, Matthew R Lamb, National AIDS Control Program (NACP), National AIDS Control Program (NACP), National AIDS Control Program (NACP), O Keiser, P Young, Redempta Mbatia, S Baveewo, S Boyer, S Moon, S Saito, SF Mugusi, SN Duda, Tanzania Commission for AIDS (TACAIDS), Tanzania Commission for AIDS (TACAIDS), Zanzibar AIDS Commission (ZAC), National Bureau of Statistics (NBS), Office of the Chief Government Statistician (OCGS), and Macro International Inc, TD Moon, The United Republic of Tanzania Ministry of Health and Social Welfare, TREAT Asia Pediatric HIV Observational Database (TApHOD), William Reidy, World Health Organisation (WHO), World Health Organisation (WHO), World Health Organization (WHO)   +50 more
core   +3 more sources

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

The Effect of Complete Integration of HIV and TB Services on Time to Initiation of Antiretroviral Therapy: A Before-After Study. [PDF]

, 2012
Studies have shown that early ART initiation in TB/HIV co-infected patients lowers mortality. One way to implement earlier ART commencement could be through integration of TB and HIV services, a more efficient model of care than separate, vertical ...
Andrew M. Boulle, Bernhard Kerschberger, David Coetzee, Eric Goemaere, Gilles Van Cutsem, Katherine Hilderbrand, Sten H. Vermund, Virginia De Azevedo   +7 more
core   +8 more sources

Quality of life in adolescents with hearing deficiencies and visual impairments

International Archives of Otorhinolaryngology, 2013
Summary Introduction: The term quality of life (in Portuguese, Qualidade de Vida; QV) has been expanded and modified over the years and has come to signify social development in terms of education, health, and leisure as well as economic ...
Vanthauze Marques Freire Torres, Christielle Lidianne Alencar Marinho, Carolina Gabriela Gomes de Oliveira, Sandra Conceição Maria Vieira   +3 more
doaj   +1 more source