Results 101 to 110 of about 3,031,333 (292)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

RAMSTRONG: AN EMPLOYEE WELLNESS INITIATIVE [PDF]

, 2016
The RAMSTRONG project’s mission is to create a mobile website accessible online and through the VCU Mobile app that provides VCU employees with user-friendly, accessible resources to support their holistic well-being.
Donaldson, Teraya, Grace E. Harris Leadership Institute, Virginia Commonwealth University, Hamlet, Tina, Hudson, Lucy, Martin, Will, Shah, Anjum, Wood, Mark, Yndestad, Lynanne   +7 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Improving Early Literacy in PreK-3: Lessons Learned [PDF]

, 2016
In 2011, The McKnight Foundation partnered with a set of districts and schools in the Twin Cities area, all serving high-needs students, on a PreK–3 literacy initiative.
Katrina Woodworth, Lauren Cassidy, Shari Golan   +2 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Comentarios a la Ley de Instituciones Locales de Euskadi desde la perspectiva de la regulación de la participación ciudadana

Revista Vasca de Administración Pública, 2017
The act is an important advance in the regulation of the regime for the Basque local institutions but it falls very short regarding the improvement of the channels for an efficient and effective citizen participation that serves for following and ...
Fernando Pindado Sánchez
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Adaptación y validación lingüística y cultural de la Escala de Medida de Agencia y Empoderamiento Personal (ESAGE) Linguistic and cultural adaptation and validation of the Scale to Measure Personal Agency and Empowerment (ESAGE)

Revista Cubana de Salud y Trabajo, 2023
Introducción: En la actualidad, medir las competencias para el empoderamiento en una organización es esencial, cada vez más se necesitan trabajadores con mayor capacidad de agencia personal, iniciativa y autonomía.
Yaíma Blanco García, Helena Moros Fernández, Damian Valdés Santiago   +2 more
doaj  

Enhancing Jewish Learning & Engagement in Preschool Life: Documenting the JRS Model [PDF]

, 2016
The Jewish Resource Specialist (JRS) Initiative, designed in 2008 by the Early Childhood Education Initiative (ECEI) of the Jewish Community Federation of San Francisco, the Peninsula, Marin and Sonoma Counties (the Federation), in partnership with the ...
Beth Cousens, Ellen Irie
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source