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Injectable hydrogels for Fenton-like Mn²⁺/Fe²⁺ delivery with enhanced chemodynamic therapy prevent osteosarcoma recurrence and promote wound healing after excision surgery. [PDF]

Mater Today Bio
Wang L, Guo H, Zhang W, Li X, Su Z, Huang X.   +5 more
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Injectable Nanocomposite Hydrogels for Cancer Therapy

Macromolecular Bioscience, 2021
AbstractHydrogel is a kind of 3D polymer network with strong swelling ability in water and appropriate mechanical and biological properties, which make it feasible to maintain bioactive substances and has promising applications in the fields of biomaterials, soft machines, and artificial tissues.
Wenzhen Du, Qida Zong, Ranran Guo, Guixia Ling, Peng Zhang   +4 more
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Injectable silk-polyethylene glycol hydrogels

Acta Biomaterialia, 2015
Silk hydrogels for tissue repair are usually pre-formed via chemical or physical treatments from silk solutions. For many medical applications, it is desirable to utilize injectable silk hydrogels at high concentrations (>8%) to avoid surgical implantation and to achieve slow in vivo degradation of the gel.
Xiaoqin, Wang, Benjamin, Partlow, Jian, Liu, Zhaozhu, Zheng, Bo, Su, Yansong, Wang, David L, Kaplan   +6 more
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Evaluation of Injectable Naloxone-Releasing Hydrogels

ACS Applied Bio Materials, 2020
The opioid epidemic in the United States is a serious public health crisis affecting over 1.7 million Americans. In the last two decades, almost 450 000 people have died from an opioid overdose, with nearly 20% of these deaths occurring in 2017 and 2018 alone.
Kaytlyn M. Crowe, Zain Siddiqui, Victoria Harbour, KaKyung Kim, Shareef Syed, Reshma Paul, Abhishek Roy, Ruhi Naik, Kayla Mitchell, Aryan Mahajan, Biplab Sarkar, Vivek A. Kumar   +11 more
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Injectable Hydrogels for Vascular Tissue Engineering

2021
Injectable scaffolds made of biodegradable biomaterials can stabilize a myocardial infarct and promote cardiac repair. Here, we describe an injectable, citrate-containing polyester hydrogel which can release citrate as a cell regulator via hydrogel degradation and simultaneously show sustained release of an encapsulated myeloid-derived growth factor ...
Fengqiao, Li, William, Ho, Xiaoyang, Xu
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Injectable hydrogels and nanocomposite hydrogels for cartilage regeneration

Journal of Biomedical Materials Research Part A, 2018
AbstractCartilage loss due to age‐related degeneration and mechanical trauma is a significant and challenging problem in the field of surgical medicine. Unfortunately, cartilage tissue can be characterized by the lack of regenerative ability. Limitations of conventional treatment strategies, such as auto‐, allo‐, and xenografts or implants stimulate an
Oliwia Jeznach, Dorota Kołbuk, Pawe Sajkiewicz   +2 more
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Injectable hydrogels for personalized cancer immunotherapies

Acta Biomaterialia, 2023
The field of cancer immunotherapy has shown significant growth, and researchers are now focusing on effective strategies to enhance and prolong local immunomodulation. Injectable hydrogels (IHs) have emerged as versatile platforms for encapsulating and controlling the release of small molecules and cells, drawing significant attention for their ...
Neda Mohaghegh, Amir Ahari, Fatemeh Zehtabi, Claire Buttles, Saya Davani, Hanna Hoang, Kaylee Tseng, Benjamin Zamanian, Safoora Khosravi, Ariella Daniali, Negar Hosseinzadeh Kouchehbaghi, Isabel Thomas, Hamed Serati Nouri, Danial Khorsandi, Reza Abbasgholizadeh, Mohsen Akbari, Rameshwar Patil, Heemin Kang, Vadim Jucaud, Ali Khademhosseini, Alireza Hassani Najafabadi   +20 more
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Mechanically Reinforced Injectable Hydrogels

ACS Applied Polymer Materials, 2019
Injectable hydrogels have garnered significant research attention in biomedical applications due to their ability to be delivered to a target site via a minimally invasive route.
Kevin J. De France, Emily D. Cranston, Todd Hoare   +2 more
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Injectable biodegradable hydrogels: progress and challenges

Journal of Materials Chemistry B, 2013
Over the past decades, injectable hydrogels have emerged as promising biomaterials because of their biocompatibility, excellent permeability, minimal invasion, and easy integration into surgical procedures. These systems provide an effective and convenient way to administer a wide variety of bioactive agents such as proteins, genes, and even living ...
Ki Hyun, Bae, Li-Shan, Wang, Motoichi, Kurisawa   +2 more
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Injectable hydrogels as unique biomedical materials

Chemical Society Reviews, 2008
A concentrated fish soup could be gelled in the winter and re-solled upon heating. In contrast, some synthetic copolymers exhibit an inverse sol-gel transition with spontaneous physical gelation upon heating instead of cooling. If the transition in water takes place below the body temperature and the chemicals are biocompatible and biodegradable, such ...
Lin, Yu, Jiandong, Ding
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