Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
A global picture of injecting drug use, HIV and anti-HCV prevalence among people who inject drugs, and coverage of harm reduction interventions. [PDF]
, 2017 Understanding how many people inject drugs is critically important for the effective provision of public health and harm reduction services. However, the severe stigma that is often attached to injecting drug use, and illicit nature of this behaviour ...
Larney, Sarah
core
Epidemiology of injecting drug use, prevalence of injecting-related harm, and exposure to behavioural and environmental risks among people who inject drugs: a systematic review. [PDF]
Lancet Glob Health, 2023 Degenhardt L +18 more
europepmc +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
Drug use and risk behaviours among injecting drug users. [PDF]
, 2005 This study focused primarily on patterns of drug use, injecting practices, risk behaviours for infectious disease, and experiences with treatment and health services among injecting drug users (IDUs) in Northern Ireland.
Jordan, Michele, McElrath, Karen
core
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Injecting drug use and unstable housing: Scope for structural interventions in harm reduction [PDF]
, 2009 Evidence links unstable housing, and especially homelessness, with elevated health harm among drug users, including riskier drug injecting practices. We undertook 45 in-depth qualitative interviews with injecting drug users (IDUs) in Bristol and London ...
Kimber, Jo +5 more
core
Counseling and Harm Reduction Centers for Vulnerable Women to HIV/AIDS in Iran.
Iranian Journal of Public Health, 2013 Human immunodeficiency virus (HIV) is a public health challenge facing both developing and developed nations. Although injecting drug use is even the main route of HIV transmission in Iran, sexual route is rising gradually.
N Fahimfar +4 more
doaj +2 more sources
Injecting drug use opportunities and reasons for choosing not to inject: A population-based study of Australian young adults who use stimulants. [PDF]
Drug Alcohol Rev, 2022 Casey LE +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source