Results 91 to 100 of about 3,571,375 (291)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Estimating the cost-effectiveness of detecting cases of chronic hepatitis C infection on reception into prison [PDF]

, 2006
Background In England and Wales where less than 1% of the population are Injecting drug users (IDUs), 97% of HCV reports are attributed to injecting drug use. As over 60% of the IDU population will have been imprisoned by the age of 30 years, prison may
Sutton, AJ, Edmunds, W. John, Edmunds, WJ, Gill, ON, Andrew J Sutton, O Noel Gill, Gill, O. N., Edmunds W John, Sutton Andrew J, Gill, O Noel, Sutton, Andrew J, Edmunds, W John, Sutton, A. J., W John Edmunds, Gill O Noel   +14 more
core   +2 more sources

Anthropology of AIDS. Risk environment and injecting routine. The case of Belgrade injecting drug users

Etnoantropološki Problemi, 2016
Risk environment is usually seen as physical and social one; first concerns physical space of injecting, while second deals with people who inject and their relations. Injecting routine is designation for set of IDUs habitual life.
Bojan Žikić
doaj   +2 more sources

The perspectives of injection drug users regarding safer injecting education delivered through a supervised injecting facility

Harm Reduction Journal, 2008
Background Unsafe injection practices are prevalent among injection drug users (IDU) and have resulted in numerous forms of drug-related harm including HIV/HCV transmission and other bacterial and viral infections.
Wood Evan, Small Will, Fast Danya, Kerr Thomas   +3 more
doaj   +1 more source

Challenges Faced and Coping Strategies Adopted by Injecting Drug Users during COVID-19 Lockdown-A Qualitative Study. [PDF]

Indian J Community Med, 2023
Vashisht S, Jha S, Kant S, Thakur N, Rai S.   +4 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Suicidal ideation and HIV risk behaviors among a cohort of injecting drug users in New Delhi, India

Substance Abuse Treatment, Prevention, and Policy, 2013
Background Data on mental health among injecting drug users in South Asia is scarce yet poor mental health among users has significant implications for the success of HIV prevention and treatment programmes.
Sarin Enisha, Singh Basant, Samson Luke, Sweat Michael   +3 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Hepatitis C Infection and Treatment among Injecting Drug Users Attending General Practice: A Systematic Review and Meta-Analysis. [PDF]

Int J Environ Res Public Health, 2023
Tandan M, Dunlea S, Bury G.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source