Results 71 to 80 of about 3,571,375 (291)
Online Journal of Health & Allied Sciences, 2017 Aim: In the last decade, the prevalence of injecting drugs has been increasing rapidly. Injecting drug use puts one at the risk of risky behaviors that affect the health of individual and society.
Farkhondeh Jamshidi +2 more
doaj
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Etnoantropološki Problemi, 2016 Social epidemiology of blood-borne diseases has been investigated in Belgrade sex workers and injecting drug users. The overall aim of the study was to reveal factors responsible for social epidemiological exposure and vulnerability of the members of ...
Bojan Žikić
doaj
Prevalence and genotypes of hepatitis C virus among injecting drug users from Salvador-BA, Brazil
Memorias do Instituto Oswaldo Cruz, 2010 Hepatitis C virus (HCV) is the major infectious disease agent among injecting drug users (IDUs), with seroprevalence ranging from 50-90%. In this paper, serological and virological parameters were investigated among 194 IDUs, 94 ex-IDUs and 95 non-IDUs ...
Maria Betânia S Silva +8 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Staphylococcal Septic Emboli in an Injection Drug User
Internal Medicine, 2013 A 35-year-old woman presented with a 1-week history of fever and malaise. She was in an acutely ill state. An HIV screening test was negative. No heart murmurs were noted on auscultation. Computed tomography revealed multiple patchy nodules throughout both lungs, some with cavitation and infiltration.
Kunimatsu, Junwa, Yoshizawa, Atsuto
openaire +3 more sources
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Injecting behaviour and service use among young injectors in Albania, Moldova, Romania and Serbia. [PDF]
, 2013 BACKGROUND: This study examines socio-demographic profiles, injecting risk and use of health services among young injectors (15-24) in Albania, Moldova, Romania and Serbia.
Scutelniciuc, Otilia +5 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source