Results 51 to 60 of about 3,571,375 (291)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Improving survey methods in sero-epidemiological studies of injecting drug users: a case example of two cross sectional surveys in Serbia and Montenegro. [PDF]

, 2009
BACKGROUND: Little is known about the prevalence of HIV or HCV in injecting drug users (IDUs) in Serbia and Montenegro. We measured prevalence of antibodies to HIV (anti-HIV) and hepatitis C virus (anti-HCV), and risk factors for anti-HCV, in community ...
Simić Danijela, Žerjav Sonja, Rhodes, T, Parry, JV, Platt Lucy, Simić Milena, Rhodes, Tim, Judd Ali, Simić, Milena, Rhodes Tim, Simić, D, Mugosa, Boban, Mugosa, B, Parry John V, Johnston, LG, Judd, A, Platt, Lucy, Mugosa Boban, Parry, John V, Simić, M, Johnston Lisa G, Simić, Danijela, Andjelkovic Violeta, Platt, L, Andjelkovic, Violeta, Zerjav, Sonja, Parry, Ruth P, Parry, RP, Johnston, Lisa G, Zerjav, S, Parry Ruth P, Andjelkovic, V, Judd, Ali   +32 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Multidisciplinary model of sexually transmitted infection prevention in the group of injecting drug users

Vestnik Dermatologii i Venerologii, 2017
The article summarizes the experience in developing, implementing and effectiveness evaluating of the sexually transmitted infection prevention program in the subpopulation of injecting drug users in St. Petersburg, Russia.
T. V. Krasnoselskikh, A. V. Shaboltas, R. V. Skochilov, G. E. Uraeva   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Exploring barriers to 'Respondent driven sampling' in sex worker and drug-injecting sex worker populations in Eastern Europe [PDF]

, 2006
Respondent driven sampling (RDS) has been used in several counties to sample injecting drug users, sex workers (SWs) and men who have sex with men and as a means of collecting behavioural and biological health data.
Platt, Lucy, Rhodes, T, Simic, Milena, Novotny, Tom, Johnston, Lisa Grazina, Sladjana Baros, Milena Simic, Violeta Andjelkovic, Baros, S, Lucy Platt, Rhodes, Tim, Lisa Grazina Johnston, Tim Rhodes, Simic, M, Platt, L, Baros, Sladjana, Andjelkovic, Violeta, Novotny, T, Tom Novotny, Johnston, LG, Andjelkovic, V   +20 more
core   +1 more source

Evaluation of immunological indices in HIV-infected patients with chronic hepatitis C in Kazakhstan

International Journal of General Medicine, 2016
Nazgul Sarsekeyeva,1,2 Bakhyt Kosherova3 1Department of Infectious Diseases and Dermatovenerology, Karaganda State Medical University, 2Karaganda Regional Center for the AIDS Prevention and Control, 3Rectorate of Karaganda State Medical University ...
Sarsekeyeva N, Kosherova B
doaj  

Opioid substitution treatment with sublingual buprenorphine in Manipur and Nagaland in Northeast India: what has been established needs to be continued and expanded

Harm Reduction Journal, 2009
Manipur and Nagaland in northeast India report an antenatal HIV prevalence of > 1% and the current HIV prevalence among injecting drug users is 24% and 4.5% respectively.
Sharma Charan, Langkham B, Natale Richard D, Kumar M Suresh, Kabi Rachel, Mortimore Gordon   +5 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

When and how do individuals transition from regular drug use to injection drug use in Uganda? Findings from a rapid assessment

Harm Reduction Journal, 2019
Background In Uganda, injection drug use is a growing but less studied problem. Preventing the transition to injection drug use may help prevent blood-borne viral transmission, but little is known about when and how people transition to injection drug ...
Matayo Baluku, Twaibu Wamala
doaj   +1 more source