Results 41 to 50 of about 675,932 (255)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Packer Sealing Failure Detection Device for Injection-production System
Shiyou jixie, 2019 In view of the difficulty and the poor timeliness of the downhole sealing and anchoring failure detection of the injection-production system, which result in production problem and energy waste, a method for early warning of release of sealing and ...
Jiang Minzheng +4 more
doaj
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
RS-LVQ-based Fault Diagnosis of the Injection-production System
Shiyou jixie, 2018 Aiming at the unconventional structure of the sucker rod pump injection-production system, an inverse calculation method was proposed. The fault diagnosis model was established and solved.
Jiang Minzheng +4 more
doaj
You-qi chuyun, 2020 Liuzhuang gas storage is reconstructed based on depleted oil and gas reservoirs. The formation pressure coefficient of injection and production gas Well X is only about 0.4 when drilling.
Fenglin YAN +4 more
doaj +1 more source
Scientific Reports, 2023 AbstractThe effect of fracture networks on EGS performance remains worth further investigation to guide the formulation of geothermal extraction strategy. We established models that account for thermo-hydraulic-mechanical (THM) coupling and that are based on the framework of discrete fracture network (DFN) to evaluate the heat extraction performance in
Zhihong Lei +3 more
openaire +3 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Research on Fault Diagnosis Method for the Sucker Rod Pump Injection-production System
Shiyou jixie, 2018 Compared with the conventional single-pump system, the structure of the sucker rod pump injection-production system is more complicated and its downhole working conditions is harsher.
Jiang Minzheng +4 more
doaj
Journal of Petroleum Exploration and Production TechnologyThe geological reserves of ordinary heavy oil suitable for thermal injection development in Bohai Oilfield are about 450 million tons. The traditional thermal recovery process uses a two trip injection-production string development method, which ...
Li Menglong +9 more
doaj +1 more source