Results 51 to 60 of about 653,335 (253)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Lubrication Pressure Injection System of Hot Rolling Line Valve Controlled Rolling

Chemical Engineering Transactions, 2018
The role of rolling lubrication technology in hot rolling production line and composition of rolling lubrication hydraulic injection system are described.
Yajun Liu, Lulu Shi, Zhongxu Lan
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Synchronous injection-production energy replenishment for a horizontal well in an ultra-low permeability sandstone reservoir: A case study of Changqing oilfield in Ordos Basin, NW China

Petroleum Exploration and Development, 2020
It is difficult to build an effective water flooding displacement pressure system in the middle section of a horizontal well in an ultra-low permeability sandstone reservoir.
Jing WANG, Jungang LIU, Zhaoguo LI, Hongchang LI, Jiaosheng ZHANG, Wenqing LI, Yuanli ZHANG, Yi PING, Huanying YANG, Ping WANG   +9 more
doaj   +1 more source

Research and Application of an Intelligent Cable-Controlled Injection–Production Integration and Control System

Processes
During offshore oilfield development, traditional injection–production processes commonly suffer from delayed regulation, low operational efficiency, and heavy reliance on manual intervention. Achieving real-time diagnosis of injection–production anomalies and dynamic optimization under complex geological conditions and harsh marine environments ...
Jianhua Bai, Zheng Chen, Wei Zhang, Zhaochuan Zhou, Liu Wang, Yuande Xu, Shaojiu Jiang, Chengtao Zhu, Zhijun Liu, Le Zhang, Zechao Huang, Qiang Wang, Zhixiong Zhang, Chenwei Zou, Xiaodong Tang, Yukun Du   +15 more
openaire   +1 more source

Numerical Study of the Influence of Injection/Production Well Perforation Location On Co2-EGS System

Energy Procedia, 2013
AbstractThe novel concept of enhanced geothermal system with CO2 instead of water as working fluid (CO2-EGS) has attracted wide attention due to additional benefit of CO2 geological storage during the power generation process. In this research, numerical investigation on a doublet CO2-EGS system is performed, focusing on the influence of the injection ...
Luo, Feng, Xu, Rui-Na, Jiang, Pei-Xue
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Orthogonal Test Analysis on Conditions Affecting Electricity Generation Performance of an Enhanced Geothermal System at Yangbajing Geothermal Field

Energies, 2017
The main conditions affecting electricity generation performance of an enhanced geothermal system (EGS) include reservoir porosity, reservoir permeability, rock heat conductivity, water production rate and injection temperature.
Yuchao Zeng, Liansheng Tang, Nengyou Wu, Jing Song, Yifei Cao   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Information System for Selection of Production Line for Plastic Item Injection Machine Number A36 Using Priority Scheduling Method

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi, 2020
A PT. Astra Components Indonesia manufactures injection plastic goods to be sent to customers, in the production process the machines used are capable of producing several types of injection plastic goods, so that products can be provided regularly and ...
Muchamad Dani Chairudin, Novita Br. Ginting, Hersanto Fajri   +2 more
doaj   +1 more source