Results 161 to 170 of about 20,589 (216)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, Volume 13, Issue 36, 29 June 2026.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Stroke-like presentation of a small tuberculum sellae meningioma unmasked by corticosteroid use: A case report. [PDF]

Radiol Case Rep
Mader C, Czabanka M, Hattingen E, Arendt CT.   +3 more
europepmc   +1 more source

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, Volume 99, Issue 6, Page 1571-1588, June 2026.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Continuous intracisternal nimodipine administration as rescue therapy for refractory vasospasm in patients with aneurysmal subarachnoid haemorrhage. [PDF]

Acta Neurochir (Wien)
Müller MD, Janosovits K, Bervini D, Mordasini P, Dobrocky T, Piechowiak EI, Schefold JC, Murek M, Goldberg J, Schucht P, Raabe A, Z'Graggen WJ.   +11 more
europepmc   +1 more source

Acute Upper Gastrointestinal Bleeding is Associated With Poor Prognosis in Patients With Biliary Tract Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Aim Upper gastrointestinal bleeding (UGIB) is associated with an unfavorable outcome in cancer patients. In patients with biliary tract cancer (BTC), data on the incidence, management, and prognostic implications of UGIB are limited. This study investigated the prevalence, treatment efficacy, and prognostic factors associated with UGIB in BTC.
Jan Christoph Schumacher, Sonja Lang, Philipp Kasper, Anna Martin, Dirk Waldschmidt, Martin Bürger, Ulrich Töx, Christoph Neumann‐Haefelin, Gabriel Allo   +8 more
wiley   +1 more source

Successful Revascularization of Chronic Total Occlusions in Patients With Chronic Thromboembolic Pulmonary Disease

Catheterization and Cardiovascular Interventions, Volume 107, Issue 7, Page 2323-2334, June 1, 2026.
ABSTRACT Background Chronic thromboembolic pulmonary disease (CTEPD) leads to chronic total occlusions (CTOs) of the pulmonary arteries in a minority of patients. Treatment of CTOs with balloon pulmonary angioplasty (BPA) may substantially improve patient hemodynamics but presents unique technical challenges and has previously been associated with a ...
Elliot J. Stein, Peter J. Leary, Lauren N. Carlozzi, Samuel G. Rayner, Zachary L. Steinberg   +4 more
wiley   +1 more source

Ultrasound-Guided Endoluminal Thermoablation of the Frontal Branch of the Superficial Temporal Artery Using a 1470-nm Laser: A Case Report. [PDF]

Cureus
Lima MF, Rios Lima MP.
europepmc   +1 more source

When Chronic Pain Clouds Acute Diagnosis: Femoral Shaft Osteonecrosis With Superimposed Pseudomonas Osteomyelitis in a Medically Complex Patient

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT In medically complex patients with chronic pain, new or worsening symptoms should prompt careful reassessment. Avascular necrosis, particularly in the setting of prolonged steroid use, may be overlooked due to diagnostic overshadowing. Timely recognition requires multidisciplinary collaboration and vigilance to distinguish acute pathology from
Ji‐Hoon Lee, Elias Lai, Jerry Markar, Bi Mo   +3 more
wiley   +1 more source

Catheter-Assisted Application of Hyaluronidase Combined With Multimodal Treatment After Hyaluronic Acid-Induced Ischemia of the Upper Extremity. [PDF]

Aesthet Surg J Open Forum
Hasiba-Pappas S, Kamolz LP, Brodmann M, Schweiger L, Pal A, Rappl T, Winter R.   +6 more
europepmc   +1 more source