Results 111 to 120 of about 26,232 (250)

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

USP7 Regulates TRPV1 Deubiquitination to Mediate Chondrocyte Ferroptosis and Alleviate Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a common degenerative joint disease characterized by chondrocyte dysfunction. In this study, we explored the function and mechanism of ubiquitin‐specific protease 7 (USP7) in chondrocyte ferroptosis in OA. The USP7, TRPV1, collagen II, and GPX4 levels in knee joint tissue were detected using immunohistochemistry ...
Jun Li, Ding Chen, Wei‐Ye Zhong
wiley   +1 more source

Osteochondral Regeneration in the Knee Joint with Autologous Peripheral Blood Stem Cells plus Hyaluronic Acid after Arthroscopic Subchondral Drilling: Report of Five Cases

Orthopaedic Surgery
Background Treatment of osteochondral defects (OCDs) of the knee joint remains challenging. The purpose of this study was to evaluate the clinical and radiological results of osteochondral regeneration following intra‐articular injections of autologous ...
Khay‐Yong Saw, Adam W. Anz, Caroline Siew‐Yoke Jee, Soo‐Fin Low, Amal Dawam, Alisha Ramlan   +5 more
doaj   +1 more source

Placebo response to intra-articular injections in knee osteoarthritis: magnitude, evolution over time, and influencing factors. A systematic review and meta-analysis with meta-regression

EFORT Open Reviews
Purpose: To quantify the response to intra-articular saline administration in terms of pain, function, and quality of life, with a focus on the evolution of placebo response over time and the identification of influencing factors on the placebo response ...
Davide Previtali, Angelo Boffa, Giorgio Di Laura Frattura, Giulia Merli, Giuseppe Filardo   +4 more
doaj   +1 more source

Intra-articular injections in the TMJ inferior joint space: a scoping review

This is a scoping review to identify the available evidence regarding intra-articular injections in the inferior joint space (IJS) of the temporomandibular joint (TMJ)
Diego De Nordenflycht, Anaís AYALA, Luis ORELLANA, Ricardo de Souza TESCH   +3 more
core   +1 more source

A single intra‐articular stromal vascular fraction with platelet‐rich plasma injection yields superior clinical outcomes than a hyaluronic acid injection in patients with knee osteoarthritis: A prospective comparative study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The present study aimed to compare the efficacy and safety of a combined injection of stromal vascular fraction (SVF) and platelet rich plasma (PRP) versus a high molecular weight (HMW) hyaluronic acid (HA) injection in patients with knee osteoarthritis (KOA).
Trifon Totlis, Vlasios Achlatis, Panagiotis‐Konstantinos Emfietzis, Theodorakys Marín Fermín, Theodoros Pettas, Aristotelis Sideridis, Ioannis Terzidis   +6 more
wiley   +1 more source

Autologous minimally manipulated adipose‐derived stromal vascular fraction in knee osteoarthritis: Lasting symptom relief and imaging evidence from a 12‐month prospective study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the safety and efficacy of intra‐articular autologous transplantation of adipose‐derived connective tissue micrografts rich in stromal vascular fraction (CTM‐SVF), obtained using an enzyme‐free system (Hy‐Tissue® SVF) for knee osteoarthritis (OA). Methods Thirty patients (mean age of 53.3 ± 6.4 years) with Kellgren–Lawrence
Laura Mangiavini, Nicolò Rossi, Riccardo Giorgino, Francesco Borelli, Alessandra Colombini, Paola De Luca, Simona Landoni, Luca Maria Sconfienza, Carmelo Messina, Irene Beriotto, Giuseppe M. Peretti, Laura de Girolamo   +11 more
wiley   +1 more source

Reduced postoperative inflammation and blood loss after robotic arm‐assisted unicompartmental compared with total knee arthroplasty: A propensity score‐matched analysis

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Robotic arm‐assisted unicompartmental knee arthroplasty (raUKA) offers potential advantages over robotic arm‐assisted total knee arthroplasty (raTKA), but its biological benefits remain unclear. Superior early recovery after raUKA may be related to reduced systemic inflammation and blood loss.
Dirk Müller, Florian Pohlig, Benjamin Schloßmacher, Vincent Lallinger, Michael T. Hirschmann, Rüdiger von Eisenhart‐Rothe, Igor Lazic   +6 more
wiley   +1 more source

Safety profile comparison of intra‐articular corticosteroids, hyaluronic acid, platelet‐rich plasma, and cell‐based injections for knee osteoarthritis: A systematic review and meta‐analysis by the ESSKA Orthobiologics Initiative

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The aim was to compare the safety profiles of corticosteroids (CS), hyaluronic acid (HA), blood‐derived products based on platelet concentrates (for simplicity indicated as PRP ‐ platelet‐rich plasma ‐ being PRP the most common product), and cell‐based therapies (namely products exploiting the therapeutic function of mesenchymal ...
Alessandro Bensa, Andrea Piano, Giacomo Arthur Fumagalli, Laura de Girolamo, Lior Laver, Jérémy Magalon, Mikel Sánchez, Thomas Tischer, Giuseppe Filardo   +8 more
wiley   +1 more source

The Effect of Intra-Articular Injections of Hyaluronic Acid for the Treatment of Trapezio-Metacarpal Joint Osteoarthritis

Background: Osteoarthritis of the basal thumb joint is a debilitating disease with a high prevalence. Among pharmacological treatments, intra-articular injections of hyaluronic acid have been clinically applied.
Federica Alviti, Nikolaos Finamore, Francesco Agostini, Marco Paoloni, Massimiliano Mangone, Elena Bressanin, Valter Santilli, Alessandro de Sire, Andrea Bernetti   +8 more
core   +1 more source