Results 141 to 150 of about 1,055,971 (285)

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source

IGF2BP3 Overexpression Accelerates Osteoarthritis Progression by Promoting Glycolysis via m6A‐Dependent Stabilization of ECM1 mRNA

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT N6‐methyladenosine (m6A) plays a critical role in osteoarthritis (OA) pathogenesis. This study investigates the role of the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 3 (IGF2BP3) in OA progression. OA models were established in vivo through destabilization of the medial meniscus (DMM) surgery in mice and in vitro by ...
Xing‐Shi Yuan, Hao‐Jie Zhang, Jia‐Xiang Ding, Zheng‐Liang Luo, Min Chen, Xiao‐Qi Zhang, Xi‐Fu Shang, Zhe Ni, Ke‐Rong Wu   +8 more
wiley   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Preserve Cartilage Homeostasis and Restore Joint Function in Experimental Osteoarthritis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mesenchymal stem cells (MSCs) have shown therapeutic potential for osteoarthritis (OA), but their clinical application is limited by the need for extensive ex vivo expansion. Human umbilical cord MSC‐derived exosomes (hUCMSC‐Exos) have emerged as a promising cell‐free alternative because of their cartilage‐protective and immunomodulatory ...
Sung‐Yen Lin, Yi‐Shan Lin, Shu‐Chun Chuang, Yi‐Wen Kuo, Cheng‐Jung Ho, Kai‐Hsuan Wang, Wei‐Cheng Tsai, Zhi‐Xiang Li, Wan‐Jung Lin, Yi‐Ju Hsieh, Chung‐Hwan Chen, Tzou‐Yien Lin   +11 more
wiley   +1 more source

Autologous minimally manipulated adipose‐derived stromal vascular fraction in knee osteoarthritis: Lasting symptom relief and imaging evidence from a 12‐month prospective study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the safety and efficacy of intra‐articular autologous transplantation of adipose‐derived connective tissue micrografts rich in stromal vascular fraction (CTM‐SVF), obtained using an enzyme‐free system (Hy‐Tissue® SVF) for knee osteoarthritis (OA). Methods Thirty patients (mean age of 53.3 ± 6.4 years) with Kellgren–Lawrence
Laura Mangiavini, Nicolò Rossi, Riccardo Giorgino, Francesco Borelli, Alessandra Colombini, Paola De Luca, Simona Landoni, Luca Maria Sconfienza, Carmelo Messina, Irene Beriotto, Giuseppe M. Peretti, Laura de Girolamo   +11 more
wiley   +1 more source

Effect of intra-articular Botulinum toxin injections on temporo-mandibular joint pain

, 2018
International audienceTemporo-mandibular joint dysfunction can be painful and disabling. In some cases, it is refractory to classical treatment. Intra-articular Botulinum toxin injections have been shown to have an anti-inflammatory and analgesic effect.
A. Huart, D. Batifol, Huart, A., Nagot, N., N. Nagot, P.J. Finiels, P. Jammet, Jammet, P., Finiels, P.J., Batifol, D.   +9 more
core   +1 more source

Safety profile comparison of intra‐articular corticosteroids, hyaluronic acid, platelet‐rich plasma, and cell‐based injections for knee osteoarthritis: A systematic review and meta‐analysis by the ESSKA Orthobiologics Initiative

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The aim was to compare the safety profiles of corticosteroids (CS), hyaluronic acid (HA), blood‐derived products based on platelet concentrates (for simplicity indicated as PRP ‐ platelet‐rich plasma ‐ being PRP the most common product), and cell‐based therapies (namely products exploiting the therapeutic function of mesenchymal ...
Alessandro Bensa, Andrea Piano, Giacomo Arthur Fumagalli, Laura de Girolamo, Lior Laver, Jérémy Magalon, Mikel Sánchez, Thomas Tischer, Giuseppe Filardo   +8 more
wiley   +1 more source

Managing the meniscus part I—Anatomy, biomechanics, and treatment strategies for the atraumatic meniscus tear

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose The purpose of this article is to serve as the first of a two‐part review on the meniscus; in this review, we will establish the background on anatomy and pathogenesis of the meniscus, as well as the effect of the meniscus on native knee kinematics and function.
Ehab M. Nazzal, Jonathan D. Hughes, Armin Runer, Matthew P. Kolevar, Jorge Chahla, Robert G. Marx, James J. Irrgang, Roman Seil, Berte Bøe, David Parker, Ryosuke Kuroda, Eric H. Senorski, Sachin Tapasvi, Volker Musahl   +13 more
wiley   +1 more source

Revision ACL reconstruction using a modified iliotibial band–allograft technique for combined ACL and lateral extra‐articular procedure achieves comparable outcomes to bone–patellar tendon–bone with modified Lemaire

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose In revision anterior cruciate ligament reconstruction (R‐ACLR), adding a lateral extra‐articular procedure (LEAP) reduces graft failure and postoperative laxity. Iliotibial band (ITB)‐based techniques may avoid patellar tendon harvesting morbidity, but evidence in adults, particularly in revision cases, remains limited.
Victor Mas, André Giardino Moreira da Silva, Thomas Ripoll, Alessandro Carrozzo, Regis Pailhe, Louis Courtot, Camilo Helito, Etienne Cavaignac   +7 more
wiley   +1 more source

Autologous adipose‐derived mesenchymal stromal cell injection for knee osteoarthritis improves pain and function without a clear increase in adverse events: A systematic review and meta‐analysis of randomized controlled trials

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To systematically review randomized controlled trials and quantitatively evaluate the efficacy and safety of injections of autologous adipose‐derived mesenchymal stromal cells (AD‐MSCs) in patients with knee osteoarthritis (OA). Methods Multiple electronic databases were searched with no date restrictions for randomized controlled ...
Joo Hyung Han, Min Jung, Kwangho Chung, Hyun‐Soo Moon, Se‐Han Jung, Seung Hoon Baik, Jeongmo Koo, Woongseob Sim, Sung‐Hwan Kim   +8 more
wiley   +1 more source

A narrative review on the translational and clinical application of platelet‐rich plasma, bone marrow concentrate and microfragmented adipose tissue for meniscal tears

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Meniscal tears are a common knee pathology with an annual incidence of 66 per 100,000 patients and are associated with pain and an increased risk of osteoarthritis (OA). Orthobiological therapies have emerged as potential adjuncts to meniscal repair, but their clinical efficacy remains unclear.
Girish Pattappa, Nicholas Müller, Johannes Zellner, Denitsa Docheva, Peter Angele   +4 more
wiley   +1 more source