Results 71 to 80 of about 26,232 (250)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

The effectiveness of hyaluronic acid intra-articular injections in managing osteoarthritic knee pain

, 2013
INTRODUCTION: Knee osteoarthritis (OA) is a common and progressive joint disease. Treatment options for knee OA vary from simple analgesia in mild cases to knee replacement for advanced disease.
Anand, Amit, Trigkilidas, D.
core   +1 more source

Ultrasound‐Guided Hip Pericapsular, Rectus Femoris Peritendinous, and Iliopsoas Bursa Injections Improve Extra‐articular Post‐arthroscopy Hip Pain

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To determine the short‐ and medium‐term efficacy of ultrasound‐guided hip pericapsular, rectus femoris peritendinous, and iliopsoas bursa injections with anesthetic and corticosteroid to treat post‐arthroscopy hip pain, and if any operative variables correlated with response likelihood.
Meghan E. Sahr, Hanley Ong, Karthik Krishnan, Shu‐Han Wang, Danyal H. Nawabi, Theodore T. Miller   +5 more
wiley   +1 more source

Ozone therapy: underestimated opportunities in the treatment of large joint diseases

Современная ревматология, 2019
Osteoarthritis (OA) and other large joint diseases remain an unsolved problem of modern orthopedics and rheumatology. The use of intra-articular injections of various drugs, including hyaluronic acid, is widespread in both our and foreign countries ...
A. N. Torgashin, S. S. Rodionova, A. V. Torgashina   +2 more
doaj   +1 more source

Efficacy and Safety Of Radiation Synovectomy with Yttrium-90 [PDF]

, 1993
In this long term retrospective study of radiation synovectomy with Yttrium-90 (Y90), we evaluated the results of 164 applications in 82 patients with RA, OA with synovitis, ankylosing spondylitis and psoriatic arthritis.
Stucki, Gerold, Bozzone, P., Treuer, E., Felder, M., Wassmer, P.   +4 more
core  

Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study

Arthritis &Rheumatology, EarlyView.
Objective To evaluate the efficacy and safety of guselkumab, an interleukin‐23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) and inadequate response (inadequate efficacy and/or intolerance) to one prior tumor necrosis factor (TNF) inhibitor.
Alexis Ogdie, Joseph F. Merola, Philip J. Mease, Christopher T. Ritchlin, Jose U. Scher, Kimberly Parnell Lafferty, Daphne Chan, Soumya D. Chakravarty, Wayne Langholff, Yanli Wang, Jie Shao, Yevgeniy Krol, Alice B. Gottlieb   +12 more
wiley   +1 more source

Intra-Articular Polyacrylamide Hydrogel Injections Are Not Innocent

Case Reports in Orthopedics, 2014
Osteoarthritis is a chronic disorder characterized by joint cartilage degeneration with concomitant changes in the synovium and subchondral bone metabolism.
Murat Tonbul, Mujdat Adas, Taner Bekmezci, Ahmet Duran Kara   +3 more
doaj   +1 more source

Intra-articular hyaluronic acid injections for hip osteoarthritis

, 2018
Although viscosupplementation has been used in the past few years both for knee and hip osteoarthritis (OA), the number of intra-articular injections and the interval between doses still remains an undetermined subject. The aim of this open retrospective
Sanfilippo Antonino, Letizia Mauro Giulia, Benedetti Maria Grazia, Scaturro Dalila   +3 more
core  

Blood Glucose Levels Following Intra-Articular Steroid Injections in Patients with Diabetes:A Systematic Review

, 2016
BACKGROUND: Parenterally administered steroids have been shown to affect the metabolism of glucose and to cause abnormal blood glucose levels in diabetic patients.
R.A. Malik, Choudhry, M N, Malik, Rayaz, M.N. Choudhry, Charalambous, Charalambos, Charalambos Panayiotou Charalambous   +5 more
core   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source