Results 91 to 100 of about 61,590 (291)

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

A Case Report on Gas Gangrene with a Fatal Outcome [PDF]

Journal of Clinical and Diagnostic Research
Gas gangrene, a life-threatening illness caused by Clostridium perfringens, progresses rapidly, resulting in systemic toxicity, multiorgan failure and ultimately death.
Priyadharshini Srinivasan, Vishak Manoj Bhaskar , Nanditha Padikkasu, Pushparani Anand   +3 more
doaj   +1 more source

MAJOR FLAWS IN TECHNIQUE OF INTRAMUSCULAR INJECTIONS

Pakistan Armed Forces Medical Journal, 2013
Objectives: To identify the major flaws in technique of administering intramuscular injections by our health care professionals and to suggest improvements based upon a scientific study. Design: Cross sectional (Jan-Feb, 2011).
Maj Sheikh Saadat Ullah Waleem, Yasser Saeed Khan, Humayun Munir Tarar   +2 more
doaj   +2 more sources

A Randomized Clinical Trial of Intravenous and Intramuscular Ketamine for Pediatric Procedural Sedation and Analgesia

Archives of Academic Emergency Medicine, 2018
Introduction: Ketamine is an agent used broadly for pediatric procedural sedation and analgesia in emergency departments. It has been found to be safe and with a low risk of complications.
Mohammad Gharavifard, Behnaz Boroumand Reza Zadeh, Hamid Zamani Moghadam   +2 more
doaj   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Tolerability of IM penicillin G benzathine diluted or not with local anesthetics, or different gauge needles for syphilis treatment: a randomized clinical trial

BMC Infectious Diseases, 2019
Background Penicillin G Benzathine (PGB) is the cornerstone of syphilis treatment. However, its intramuscular (IM) administration is associated with pain at the site of injection.
Vicente Estrada, Eva Santiago, Inmaculada Cabezas, Juan Luis Cotano, Juan Carlos Carrió, Manuel Fuentes-Ferrer, Mar Vera, Oskar Ayerdi, Carmen Rodríguez, Laura López, Noemí Cabello, María José Núñez, Teresa Puerta, Iñigo Sagastagoitia, Jorge Del Romero   +14 more
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Randomized clinical trial to assess pain and bruising in medicines administered by means of subcutaneous and intramuscular needle injection: Is it necessary to have needles changed?

Revista Latino-Americana de Enfermagem
This clinical trial aimed at comparing the intensity of pain and bruising by subcutaneous and intramuscular injections using and retractable fixed syringes and needles and syringes with no needles combined, at a public hospital in Sao Paulo, for six ...
Luiz Carlos Ribeiro Lamblet, Edilson Sant'Anna Meira, Silvana Torres, Barbara Carvalho Ferreira, Sergio Dias Martucchi   +4 more
doaj  

Should Not The Dorsogluteal Site Be Used for Intramuscular Injection?

Florence Nightingale Journal of Nursing, 2019
The present review was conducted for the purpose of explaining the reasons why the dorsogluteal site should not use for intramuscular injection based on evidence.
Nurten KAYA, Nuray TURAN, Aylin ÖZTÜRK PALLOŞ   +2 more
doaj  

Pain and intramuscular injections [PDF]

Anaesthesia, 2004
J M, Cupitt, V, Kasipandian
openaire   +2 more sources