Results 81 to 90 of about 61,590 (291)

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

The Study in Animal Models of Local Action, Acute and Chronic Toxicity of Inactivated Influenza Vaccine Ultriks in Syringe

Эпидемиология и вакцинопрофилактика, 2015
The evaluation of acute and chronic toxicity and local effect of the inactivated influenza vaccine Ultriks in animal models (guinea pigs, mice BALB/c) was performed.
O. G. Kurskaya, K. A. Sharshov, A. Yu. Alekseev, M. A. Gulyaeva, A. M. Shestopalov, L. V. Shestopalova, G. M. Ignatev, V. A. Shkurupiy   +7 more
doaj   +1 more source

Administering intramuscular injections how does research translate into practice over time in the mental health setting? / [PDF]

, 2015
Background: Increasingly, mental health nurses are expected to base their clinical practice on evidence based knowledge and many of the practice traditions that have passed between generations of nurses must now be examined within this scientific context.
Wynaden, Dianne, Sourinathan, Vijay., L Barr (9879686), J Tohotoa (9877568), Happell, B., O Al Omari (9877571), K Heslop (9877574), Heslop, Karen., Barr, Lesley., D Wynaden (9852572), Barr, L., Happell, Brenda., Helsop, Karen, Brenda Happell (9801788), Tohotoa, Jenny., Sourinathan, V., Sourinathan, Vijay, Heslop, Karen, Barr, Lesley, Al Omari, Omar, V Sourinathan (9879689), Wynaden, Dianne., Tohotoa, Jenny, HAPPELL, Brenda, Al Omari, Omar.   +24 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Necrotizing Soft Tissue Fasciitis after Intramuscular Injection

Case Reports in Surgery, 2018
Necrotizing soft tissue fasciitis (NSTIs) or necrotizing fasciitis is an infrequent and serious infection. Herein, we describe the clinical course of a female patient who received a diagnosis of NSTIs after gluteus intramuscular injection. We also report
Angelica Abbate, Piero Luigi Almasio, Martina Mongitore, Gaetano Di Vita, Rosalia Patti   +4 more
doaj   +1 more source

Segurança do paciente na administração de medicamento intramuscular em pediatria: avaliação da prática de enfermagem

Revista Gaúcha de Enfermagem, 2018
Resumo OBJETIVOS Avaliar a prática de Enfermagem quanto à administração de medicamento por via intramuscular na pediatria. MÉTODOS Descritivo, observacional, quantitativo, desenvolvido mediante 327 observações da administração de medicamento ...
Thais Lima Vieira De Souza, Rafaela de Oliveira Mota, Eva Anny Wélly de Souza Brito, Laryssa Miranda Vidal Cavalcante Farias, Érica Oliveira Matias, Francisca Elisângela Teixeira Lima   +5 more
doaj   +1 more source

Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery

Advanced Science, EarlyView.
Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae, Jisun Lee, Jae‐Hun Ahn, Hosam Choi, Huijeong Choi, Jungmin Kim, Minho Kang, Ho Rim Oh, So Hyun Park, Eun Young Oh, Sanghyuk Jeon, Yeeun Lee, Yu‐Sun Lee, Na‐Young Lee, Hee‐Jin Bae, Jina Kwak, Jooil Kim, Nakyung Lee, Beomsun Kang, Ji‐Hye Kim, Eunsaem Song, Daesub Song, Hyunho Yoon, Sang‐Myeong Lee, Hyewon Youn, Kiyoun Lee, Byeong‐Cheol Kang, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Save application of injections [PDF]

, 2012
This thesis fouses on a save application of intramuscular injections. In this work I am fousing mainly on applications of the injections into musculus gluteus maximus. The goal of my thesis is to find out, if nurses know and control the correct technique
Machová, Anna
core   +2 more sources