Results 241 to 250 of about 120,047 (307)

Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport. [PDF]

Gastroenterology
Kesaraju S, Li Y, Xing J, Ghadiri M, Tracy M, Wannemo K, Holder A, Zhao P, Wu Q, Khan MA, Wood S, Durgam S, Kainov J, Rana N, Sidahmed M, Hyoju S, Smith L, Matthews JM, Wu R, Tay S, Khalili-Araghi F, Geisz-Fremy A, Rana M, Oakes SA, Shen L, Weber CR.   +25 more
europepmc   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Hochuekkito attenuates anxiety-like behavior associated with pulmonary inflammation induced by intratracheal lipopolysaccharides in mice. [PDF]

Front Pharmacol
Izushi Y, Ushio S, Ueda T, Tasaka Y, Miyazaki I, Asanuma M, Kitamura Y.   +6 more
europepmc   +1 more source

Hepatoma‐Derived Growth Factor Coordinates STAT3 Pathway and Exosome‐Mediated Intrahepatic Crosstalk to Control Hepatic Steatosis and MASLD

Advanced Science, EarlyView.
Hepatic HDGF as a key mediator in coordinating hepatic steatosis and intrahepatic crosstalk in MASLD. Activation of HDGF facilitates its interaction with both STAT3 and S6K1, driving the S6K1‐dependent STAT3 phosphorylation and subsequently enhancing hepatic lipogenesis.
Jian Wen, Dong Ding, Zengpeng Zheng, Xufeng Chen, Wenjing Li, Jiaxin Shen, Zhiwei Huang, Peng Tan, Junjie Bai, Xia Fang, Baofang Xing, Puyuan Hu, Linghao Xu, Haokai Yu, Yixi Wang, Zongzhe Jiang, Yang Long, Tiejun Zhou, Mingxin Ye, Yu Jiang, Aoyuan Cui, Hong Li, Qiurong Ding, Yong Xu, Yu Li, Weitong Su, Feng Shen, Chenlin Gao, Wenguang Fu   +28 more
wiley   +1 more source

Adolescent Vitamin D Supplementation Reverses Neuroplasticity and Motivational Deficits Induced by Developmental Alcohol Exposure and Early-Life Stress. [PDF]

Int J Dev Neurosci
Alves AP, Bianco CD, Fernandes CM, Hübner IC, Brocardo PS.   +4 more
europepmc   +1 more source

Modulation of Gut Microbes and Hepatic Metabolites by PCP Ameliorates NASH and Fatigue-like Performance in Mice. [PDF]

Nutrients
Hong Y, Yang J, Wang Y, Chen D, Wu A, Li M, Ou W, Lin G, Lin C, Liang Y.   +9 more
europepmc   +1 more source

Mapping the immune and epigenetic landscape of medication-overuse headache (MOH): a systematic review. [PDF]

Front Immunol
Andersen NE, Waliszewska-Prosół M, Pellesi L.   +2 more
europepmc   +1 more source

CXCL1: a novel therapeutic target to increase aneurysm healing after coil embolization. [PDF]

Front Stroke
Patel D, Martinez M, Saengchote SA, Motwani K, Dodd WS, Segherlou ZH, Xu H, Hosaka K, Hoh BL.   +8 more
europepmc   +1 more source