Results 11 to 20 of about 140,443 (305)

Pharmacokinetics of oxiracetam and its degraded substance (HOPAA) after oral and intravenous administration in rats

Asian Journal of Pharmaceutical Sciences, 2014
The pharmacokinetics of oxiracetam and its degraded substance (4-hydroxy-2-oxo-1-pyrrolidine acetic acid, HOPAA) after oral and intravenous administration in rats were studied using an established UPLC-MS/MS method.
Xinhuan Wan, Xiaohong Liu, Zheng Liu, Panqin Ma, Feitong Zhang, Xiangrong Zhang, Jin Sun   +6 more
doaj   +2 more sources

Biodistribution of PET radiotracers in tumor-bearing TRAMP mice administered by retroorbital or jugular vein injections

Scientific Reports
Nuclear medicine is an important tool for use in molecular imaging of important biological processes. Methods for intravenous delivery of radiotracers remains a challenge, with tail vein injections demonstrated to be technically difficult and lacking in ...
Catherine C. Applegate, Michael B. Nelappana, Yuxiao Cui, Goodluck Okoro, Elaine A. Nielsen, Nicolas P. Dovalovsky, Andrew M. Smith, Iwona T. Dobrucki, Lawrence W. Dobrucki   +8 more
doaj   +2 more sources

Utilities associated with subcutaneous injections and intravenous infusions for treatment of patients with bone metastases

Patient Preference and Adherence, 2013
Louis S Matza,1 Ze Cong,2 Karen Chung,2 Alison Stopeck,3 Katia Tonkin,4 Janet Brown,5 Ada Braun,2 Kate Van Brunt,6 Kelly McDaniel1 1Outcomes Research, United BioSource Corporation, Bethesda, MD, USA; 2Amgen, Inc, Thousand Oaks, CA, USA; 3Department of ...
Matza LS, Cong Z, Chung K, Stopeck A, Tonkin K, Brown J, Braun A, Van Brunt K, McDaniel K   +8 more
doaj   +1 more source

Assessment of the Toxicity and the Stability of Saeng Mak San by Using Repeated Intravenous Injections in Sprague-Dawley Rats

Journal of Pharmacopuncture, 2016
Objectives: This study used repeated intravenous injections of Saeng Maek San (SMS) injection in Sprague-Dawley (SD) rats to assess the toxicity and the stability of SMS Methods: Six-week-old male and female SD rats reared by Orient bio Inc were chosen ...
Hwa-Young Lee, Sungchul Kim, Seung-Hun Cho   +2 more
doaj   +2 more sources

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Administration JMKX003142 in Chinese Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Single, and Multiple Ascending Dose Phase I Clinical Trial [PDF]

Drug Design, Development and Therapy
Cheng Cui,1– 3 Jixiang Zhu,1,2 Zhiping Liu,1– 3 Jingyao Liu,1,2 Xiaomin Huang,1,2 Yi Liu,4 Jingqiu Hu,4 Lingli Zhang,4 Xue Zhang,4 Yila Sha,4 Dongyang Liu,1– 3 Haiyan Li1– 3 1Drug Clinical Trial Center, Department of Pharmacy, Peking University Third ...
Cui C, Zhu J, Liu Z, Liu J, Huang X, Liu Y, Hu J, Zhang L, Zhang X, Sha Y, Liu D, Li H   +11 more
doaj   +2 more sources

Healthcare-associated HIV outbreaks in Pakistan: a preventable public health crisis [PDF]

Public Health Action
F. Malik
doaj   +2 more sources

The Effects of Trends in Osteoporosis Treatment on the Incidence of Fractures

Journal of Osteoporosis, 2021
Summary. We analyzed the data about the preferences of medication and incidence of fractures between osteoporosis patients from 2012 to 2016. Our results suggested that the number of patients treated with intravenous and subcutaneous injections increased
Akira Horikawa, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Yoichi Shimada, Hiroyuki Kodama, Akihisa Sano   +6 more
doaj   +1 more source

Secondary venous aneurysm following intravenous drug abuse: A case report [PDF]

Vojnosanitetski Pregled, 2016
Introduction. Venous aneurysm (VA) is a rare condition that can be presented in both superficial and deep venous system. Secondary VAs as well as pseudoaneurysms are usually caused by external spontaneous or iatrogenic trauma.
Marković Miroslav, Dragaš Marko, Končar Igor, Banzić Igor, Pejkić Siniša, Fatić Nikola, Davidović Lazar   +6 more
doaj   +1 more source

Comparison between intratumoral and intravenously administered oncolytic virus therapy with Newcastle disease virus in a xenograft murine model for pancreatic adenocarcinoma

Heliyon, 2022
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor clinical prognosis and is usually a metastatic disease. In the last decades, oncolytic viro-immunotherapy has shown a promise as treatment strategy with encouraging results for a variety ...
J. Fréderique de Graaf, Marco Huberts, Daphne Groeneveld, Stefan van Nieuwkoop, Casper H.J. van Eijck, Ron A.M. Fouchier, Bernadette G. van den Hoogen   +6 more
doaj   +1 more source

Safety, biodistribution and viral shedding of oncolytic vaccinia virus TG6002 administered intravenously in healthy beagle dogs

Scientific Reports, 2021
Oncolytic virotherapy is an emerging strategy that uses replication-competent viruses to kill tumor cells. We have reported the oncolytic effects of TG6002, a recombinant oncolytic vaccinia virus, in preclinical human xenograft models and canine tumor ...
Jérémy Béguin, Murielle Gantzer, Isabelle Farine, Johann Foloppe, Bernard Klonjkowski, Christelle Maurey, Éric Quéméneur, Philippe Erbs   +7 more
doaj   +1 more source