Cocaine self-administration in the mouse: A low-cost, chronic catheter preparation [PDF]
, 2012 Intravenous drug self-administration is the most valid animal model of human addiction because it allows volitional titration of the drug in the blood based on an individual’s motivational state together with the pharmacokinetic properties of the ...
Brian A. Cadle +3 more
core +3 more sources
Frontiers in Veterinary Science, 2020 Objectives: We aimed to determine the effect of intravenous morphine injection on the modified Frankel scores of dogs with thoracolumbar intervertebral disk extrusion (IVDE).Methods: This was a prospective, blinded, randomized, and placebo-controlled ...
Aurore Fouhety +6 more
doaj +1 more source
Noninvasive depth estimation using tissue optical properties and a dual-wavelength fluorescent molecular probe in vivo [PDF]
, 2017 Translation of fluorescence imaging using molecularly targeted imaging agents for real-time assessment of surgical margins in the operating room requires a fast and reliable method to predict tumor depth from planar optical imaging.
Achilefu, Samuel +4 more
core +2 more sources
Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice [PDF]
, 2006 Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A +4 more
core
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]
, 1993 Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR +3 more
core +1 more source
Haematologica, 2017 Intravenous rituximab plus chemotherapy is standard treatment for diffuse large B-cell lymphoma. A subcutaneous formulation of rituximab is expected to simplify and shorten drug preparation and administration, and to reduce treatment burden.
Pieternella Lugtenburg +11 more
doaj +1 more source
The site of emetic action of veratrum derivatives. [PDF]
, 1951 Thesis (M.A.)--Boston ...
Swiss, Edward D
core +1 more source
A Leprolina "Souza-Araujo" no tratamento da lepra
Memorias do Instituto Oswaldo Cruz, 1948 The A. summarizes clinical records of four lepers treated with Leprolin “Souza-Araujo”, as follow: ist – Male, 28 years old, lepromatous case, treated during about 3 years, who received 80 injections of the antigen, being 52 by vene, 18 by muscle and 10 ...
José Mariano
doaj +1 more source
Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics
Advanced Science, 2023 Proteins are among the most common therapeutics for the treatment of diabetes, autoimmune diseases, cancer, and metabolic diseases, among others. Despite their common use, current protein therapies, most of which are injectables, have several limitations.
Alexander M. Curreri +6 more
doaj +1 more source
Harnessing subcellular-resolved organ distribution of cationic copolymer-functionalized fluorescent nanodiamonds for optimal delivery of therapeutic siRNA to a xenografted tumor in mice [PDF]
, 2020 Diamond nanoparticles (nanodiamonds) can transport active drugs in cultured cells as well as in vivo. However, in the latter case, methods allowing to determine their bioavailability accurately are still lacking. Nanodiamond can be made fluorescent with a perfectly stable emission and a lifetime ten times longer than the one of tissue autofluorescence.
arxiv +1 more source