Results 51 to 60 of about 455,846 (303)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

A Leprolina "Souza-Araujo" no tratamento da lepra

Memorias do Instituto Oswaldo Cruz, 1948
The A. summarizes clinical records of four lepers treated with Leprolin “Souza-Araujo”, as follow: ist – Male, 28 years old, lepromatous case, treated during about 3 years, who received 80 injections of the antigen, being 52 by vene, 18 by muscle and 10 ...
José Mariano
doaj   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Transversus Abdominis Plane Catheter Bolus Analgesia after Major Abdominal Surgery

Anesthesiology Research and Practice, 2012
Purpose. Transversus abdominis plane (TAP) blocks have been shown to reduce pain and opioid requirements after abdominal surgery. The aim of the present case series was to demonstrate the use of TAP catheter injections of bupivacaine after major ...
Nils Bjerregaard, Lone Nikolajsen, Thomas Fichtner Bendtsen, Bodil Steen Rasmussen   +3 more
doaj   +1 more source

Real-world response rates in patients with human epidermal growth factor receptor 2-positive breast cancer after neoadjuvant treatment using dual human epidermal growth factor receptor 2 blockade

Frontiers in Oncology
IntroductionBreast cancer (BC) is the most commonly diagnosed malignancy among women globally and in India. The human epidermal growth factor receptor 2 (HER2)-positive subtype is associated with aggressive disease and poorer prognosis; however ...
Abdul Shahid Poovathum Parambil, Abul Hussain Mirsa, Azgar Abdul Rasheed, Arun Vasudevan   +3 more
doaj   +1 more source

Distraction using virtual reality for children during intravenous injections in an emergency department: A randomized trial

, 2022
[[abstract]]Aim and objectives: To determine whether the virtual reality as a distracting intervention could reduce pain and fear in school-age children receiving intravenous injections at an emergency department. Background: An intravenous injection is
Lai, Chi-Hsiu, Chen, Yen-Ju, Cheng, Su-Fen, Hou, I-Ching, Chen, Chi-Wen, Lee, Pi-Chang   +5 more
core  

The safe insertion of peripheral intravenous catheters : a mixed methods descriptive study of the availability of the equipment needed [PDF]

, 2012
Background: Intravenous cannulation is undertaken in a high proportion of hospitalised patients. Much international attention has been given to the use of care bundles to reduce the incidence of infection in these patients.
Alison Holmes, Franklin, BD, Cooke, M, Holmes Alison, Vincent Charles, Cooke, Matthew (Professor of clinical systems design), Vincent, Charles, Charles Vincent, Vincent, C, Deelchand Vashist, Matthew Cooke, Franklin, Bryony Dean, Cooke, Matthew W, Franklin, Bryony, Holmes, A, Holmes, Alison H., Cooke Matthew, Vashist Deelchand, Deelchand, V, Franklin Bryony, Bryony Franklin, Vincent, Charles, Dr., Holmes, Alison, Deelchand, Vashist   +23 more
core   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics

Advanced Science, 2023
Proteins are among the most common therapeutics for the treatment of diabetes, autoimmune diseases, cancer, and metabolic diseases, among others. Despite their common use, current protein therapies, most of which are injectables, have several limitations.
Alexander M. Curreri, Jayoung Kim, Michael Dunne, Pavimol Angsantikul, Morgan Goetz, Yongsheng Gao, Samir Mitragotri   +6 more
doaj   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source