Results 1 to 10 of about 86,966 (293)

AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord [PDF]

Molecular Therapy: Methods & Clinical Development, 2021
AAV vectors are being used extensively for gene-modifying therapies for neurological disorders. Here, we report the surprising discovery that injections of different AAVs into the brain, spinal cord, or cerebrospinal fluid (CSF) lead to robust ...
Oswald Steward, Aminata P. Coulibaly, Mariajose Metcalfe, Jamie M. Dam, Kelly M. Yee   +4 more
doaj   +2 more sources

Study Protocol- Lumbar Epidural Steroid Injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults [PDF]

BMC Musculoskeletal Disorders, 2012
Background Lumbar spinal stenosis is one of the most common causes of low back pain among older adults and can cause significant disability. Despite its prevalence, treatment of spinal stenosis symptoms remains controversial.
Friedly Janna L, Bresnahan Brian W, Comstock Bryan, Turner Judith A, Deyo Richard A, Sullivan Sean D, Heagerty Patrick, Bauer Zoya, Nedeljkovic Srdjan S, Avins Andrew L, Nerenz David, Jarvik Jeffrey G   +11 more
doaj   +2 more sources

Comparison of transforaminal and interlaminar epidural steroid injections for the treatment of chronic lumbar pain

Revista Brasileira de Anestesiologia, 2017
Study design: A cross-sectional study. Objective: We compared the 12 month outcomes of fluoroscopically guided transforaminal epidural steroid injections with interlaminar epidural steroid injections for the treatment of chronic lumbar spinal pain ...
Serbülent Gökhan Beyaz
doaj   +4 more sources

Appearance and vanishing of a spinal intradural arachnid cyst after multiple epidural corticosteroid injections. A spontaneously resolving cause of symptomatic lumbar stenosis

Journal of the Belgian Society of Radiology, 2014
'Background: 'Spinal intradural arachnoid cyst is a rare lesion, sometimes acquired. 'Purpose: 'To describe the appearance and later spontaneous disappearence of a lumbar intradural arachnoid cyst, following perineural corticoid injections.
P Mailleux, G Milbouw, G Koerts, P Verbeek, X Willems   +4 more
doaj   +3 more sources

Managing intrathecal administration of nusinersen in adolescents and adults with 5q-spinal muscular atrophy and previous spinal surgery [PDF]

Arquivos de Neuro-Psiquiatria
Background: Spinal muscular atrophy (SMA) is a neurodegenerative disease of lower motor neurons associated with frequent occurrence of spinal deformity.
Rodrigo de Holanda Mendonça, Hermann dos Santos Fernandes, Rafael Barbéro Schimmelpfeng Pinto, Ciro Matsui Júnior, Graziela Jorge Polido, André Macedo Serafim da Silva, Luis Fernando Grossklauss, Umbertina Conti Reed, Edmar Zanoteli   +8 more
doaj   +3 more sources

Effective radiation dose reduction in computed tomography-guided spinal injections: a prospective, comparative study with technical considerations

Orthopedic Reviews, 2012
Despite the good general patient acceptance, high patient comfort, safety and precision in the needle placement, exposure to radiation in computed tomography (CT)- guided spinal interventions remains a serious concern, and is often used to argue against ...
Juraj Artner, Friederike Lattig, Heiko Reichel, Balkan Cakir   +3 more
doaj   +2 more sources

Epidural injections with or without steroids in managing chronic low back pain secondary to lumbar spinal stenosis: a meta-analysis of 13 randomized controlled trials

Drug Design, Development and Therapy, 2015
Hai Meng, Qi Fei, Bingqiang Wang, Yong Yang, Dong Li, Jinjun Li, Nan Su Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China Background: Epidural injections of ...
Meng H, Fei Q, Wang B, Yang Y, Li D, Li J, Su N   +6 more
doaj   +1 more source

Steroid for epidural injection in spinal stenosis: a systematic review and meta-analysis

Drug Design, Development and Therapy, 2015
Kuan Liu,* Pengcheng Liu,* Run Liu, Xing Wu, Ming Cai Department of Orthopaedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China *These authors contributed equally to this work ...
Liu K, Liu PC, Liu R, Wu X, Cai M
doaj   +1 more source

Nusinersen Administration in Spinal Muscular Atrophy Patients with Severe Scoliosis: Interlaminar Approaches at the Lumbar Level [PDF]

Annals of Child Neurology, 2020
Purpose Spinal muscular atrophy (SMA) is a genetic progressive neuromuscular disorder, and nusinersen has shown to improve its symptoms. Scoliosis is a frequent symptom in patients with SMA and complicates the intrathecal injection of nusinersen. The aim
Joo Young Song, Hyun Su Kim, Se-Jun Park, Jiwon Lee, Jeehun Lee   +4 more
doaj   +1 more source

Pressure-Volume Relationships in the Spinal Canal and Potential Neurological Complications After Epidural Fluid Injections

Frontiers in Pain Research, 2022
High-volume fluid injections into the spinal canal may lead to severe neurological complications. But when anatomical or pathological conditions in the spinal canal are unfavorable, even small volume epidural injections can cause dangerously high ...
Hemmo Bosscher
doaj   +1 more source