Results 121 to 130 of about 86,966 (293)

The distribution patterns of neurons in the spinal cord that were retrogradely labeled from the rostral ventromedial medulla.

, 2013
Schematic drawings showing the brainstems of three rats with fluorescent microsphere injections (blue, purple and red) and the corresponding spinal cords with the distribution of retrogradely labeled neurons (filled black circles), and retrogradely ...
Somesh K. Kohli (324278), Mehdi Hossaini (324275), Jan C. Holstege (324281), Jacqueline A. C. Goos (324276)   +3 more
core   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Intradetrusor Injections of Botulinum Toxin A in Adults with Spinal Dysraphism

, 2018
International audiencePurpose:The aim of the current study was to determine the outcomes of botulinum toxin A intradetrusor injections in adult patients with spina bifida.Materials and methods:All patients with spinal dysraphism who underwent ...
Biardeau, Xavier, Cornu, J.N., Boutin, J.M., Benoit Peyronnet, Gilles Karsenty, Véronique Phé, Gérard Amarenco, Baron, M., Capon, Grégoire, Phé, V., Game, X., Marianne De Seze, Amarenco, Gérard, Saussine, Christian, Gamé, Xavier, Amarenco, G., Schurch, Brigitte, Saussine, C., Andrea Manunta, Biardeau, X., de Seze, Marianne, Perrouin-Verbe, M.A., Even, Alexia, Hascoet, J., Xavier Game, Christian Saussine, null null, Chartier-Kastler, Emmanuel, Alexia Even, Manunta, A., Baron, Maximilien, Jean-Michel Boutin, Marie-Aimée Perrouin-Verbe, De Seze, M., Lenormand, L., Cornu, Jean-Nicolas, Manunta, Andrea, Pierre Denys, Denys, P., Perrouin-Verbe, Marie-Aimée, Capon, G., Xavier Biardeau, Peyronnet, B., Juliette Hascoet, Jean-Nicolas Cornu, Phe, Veronique, Schurch, B., Karsenty, Gilles, Loic Lenormand, Denys, Pierre, Grégoire Capon, Brigitte Schurch, Peyronnet, Benoit, Boutin, Jean-Michel, Emmanuel Chartier-Kastler, Chartier-Kastler, E., Even, A., Hascoet, Juliette, Karsenty, G., Lenormand, Loic, Maximilien Baron   +60 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Prolotherapy injections for chronic low-back pain

, 2007
Background: Prolotherapy involves repeated injections of irritant solutions to strengthen lumbosacral ligaments and reduce some types of chronic low‐back pain; spinal manipulation and exercises are often used to enhance its effectiveness. Objectives:
Schoene, ML, Yelland, Michael J, Schoene, Mark L., Schoene, M L, Dagenais, S, Del Mar, Chris, Yelland, Michael J., Del Mar, Chris B, Dagenais, Simon, Yelland, MJ, Del Mar, C   +10 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Long-term effects of repeated injections of local anesthetic with or without corticosteroid for lumbar spinal stenosis: A randomized trial

, 2017
OBJECTIVE: To determine the overall long-term effectiveness of treatment with epidural corticosteroid injections for lumbar central spinal stenosis and the effect of repeat injections, including crossover injections, on outcomes through 12 months. DESIGN:
Comstock, Bryan A, Turner, Judith A, Standaert, Christopher J, Smuck, Matthew, Deyo, Richard A, Bauer, Zoya, Kennedy, David J, Rundell, Sean D, Avins, Andrew L, Jarvik, Jeffrey G, Nerenz, David R, Akuthota, Venu, Friedly, Janna L, Shi, Xu R, Kessler, Larry, Sibell, David, Suri, Pradeep, Chen, Allen S, Heagerty, Patrick J, Wasan, Ajay D, Annaswamy, Thiru, Diehn, Felix, Nedeljkovic, Srdjan S   +22 more
core  

tBid‐Mediated Genetic Ablation of Connective Tissue Cells Reveals Their Key Regulatory Function During Limb Regeneration in Axolotls

Advanced Science, EarlyView.
We establish a tBid‐mediated cell ablation system in axolotls, achieve rapid and efficient ablation of multiple cell types, including muscle stem cell, spinal cord cell, and connective tissue (CT) cells. We investigate the role of CT using tBid‐mediated CT ablation and identify its essential role for limb development and regeneration.
Yan Hu, Weimin Feng, Zitian He, Jiayi Zeng, Jingyi Tang, Shulin Li, Tongbo Yu, Sulei Fu, Hui Ma, Binbin Lu, Yanmei Liu, Ji‐Feng Fei   +11 more
wiley   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source