Results 141 to 150 of about 86,966 (293)

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Harms of selected spinal and paraspinal injections and denervation procedures for chronic non-cancer spine pain: a systematic review and meta-analysis of non-randomised studies. [PDF]

BMJ Open
Malam F, Asif S, Khalid F, Leafloor C, Hong P, Levit T, Zeraatkar D, Wang L, Couban R, Agarwal A, Agarwal A, Agoritsas T, Busse JW.   +12 more
europepmc   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Effectiveness of transforaminal steroid injections in spinal canal stenosis grade 1 to 3

Introduction: Transforaminal injections have been associated with rare but major complications. Despite several studies on epidural steroid injection as a minimally invasive non-surgical method to relieve the pain of spinal canal stenosis, there is no ...
Mahmoodkhani, M., Donya Sheibani Tehrani, Rezvani, M., Navid Hajiabbasi, M., Askariardehjani, N., Mohammad Navid Hajiabbasi, Sheibani Tehrani, D., Mehdi Mahmoodkhani, Navid Askariardehjani, Majid Rezvani   +9 more
core   +1 more source

Characterisation of cold-selective lamina I spinal projection neurons in the mouse. [PDF]

Elife
Razlan AN, Ma W, Dickie AC, Polgar E, McFarlane AG, Yadav M, Cooper AH, Strathdee D, Watanabe M, Bell AM, Todd AJ, Hachisuka J.   +11 more
europepmc   +1 more source

Drug‐Induced Cuproptosis Defines the Therapeutic Window of Celecoxib in Intervertebral Disc Degeneration via the HSP90‐RBX1 Axis

Advanced Science, EarlyView.
This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo, Hongju Xiao, Shenghao Ba, Yu Zhou, Bijun Wang, Bin Yu, Yufeng Huang, Haihong Zhao, Zhefan Stephen Chen, Na Shen, Zhaoyu Ba, Desheng Wu   +11 more
wiley   +1 more source

Lumbar Spinal Stenosis Severity by CT or MRI Does Not Predict Response to Epidural Corticosteroid versus Lidocaine Injections

, 2019
BACKGROUND AND PURPOSE: Epidural steroid injections may offer little-to-no short-term benefit in the overall population of patients with symptomatic spinal stenosis compared with lidocaine alone.
Nedeljkovic, S S, Heagerty, P J, Aghayev, E, Hwang, W D, Nerenz, David R, Jitjai, D, Schwalb, Jason M, Friedly, J L, Annaswamy, T, Jarvik, E R, Avins, A L, Diehn, F E, Jarvik, J G, Bauer, Z, Haynor, D, Perez, F A, Standaert, C J, Nguyen, Q T, Quinet, S   +18 more
core  

Artificial Intelligence for Procedural Guidance of Spinal Epidural Steroid Injections: A Scoping Review. [PDF]

Cureus
DeVries A, Yuska T, Riskin SI.
europepmc   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source