Results 151 to 160 of about 494,696 (297)

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

Effect of Preoperative Epidural Spinal Injections on Complications After Posterior Lumbar Interbody Fusion. [PDF]

Global Spine J
Saint-Clair D, Gopinatth V, Dawit B, Jones H, Yim A, Kark J, Yoo JU.   +6 more
europepmc   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Minimally Invasive Spinal Interventions for Back and Neck Pain in the Pediatric Population: a Systematic Review. [PDF]

Curr Pain Headache Rep
Jevotovsky D, Dovlatyan R, Mermelstein S, Banks D, Medina R, Dukat A, Lee C, Hirani S, Portugal S, McKay TE.   +9 more
europepmc   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Anatomical validation of ultrasound-guided retrolaminar block for the treatment of symptomatic vertebral fragility fractures. [PDF]

Front Med (Lausanne)
Ponce A, Sala X, Gómez-Casanovas E, Llusá M, Gómez-Puerta JA, Peris P.   +5 more
europepmc   +1 more source

Study of effectiveness of bronchial clearence in subjects with upper spinal cord injuries. Examination of a rehabilitation programme involving mechanical insufflation and exsufflation

, 2004
Study design: this randomized controlled trial designed to establish the effectiveness of mechanical insufflation and exsufflation in post-tracheostomy subjects with upper spinal cord injuries (C1-C7), ASIA A classification and bronchial hypersecretion.
PILLASTRINI, PAOLO, BORDINI S., MENARINI, MAURO   +2 more
core  

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Targeted knockdown of Smn in muscle stem cells induces non-cell autonomous loss of motor neurons. [PDF]

Brain
Mecca J, Mignot J, Gervais M, Ozturk T, Astord S, Berthier J, Bauché S, Messéant J, Biferi MG, Rouard H, Barkats M, Relaix F, Didier N.   +12 more
europepmc   +1 more source