Results 231 to 240 of about 494,696 (297)

Exploring Genetic Therapies Targeting Amyotrophic Lateral Sclerosis in Animal Models: A Systematic Review and Meta-Analysis. [PDF]

J Gene Med
Wedgwood HE, Tuxworth RI, Ahmed Z.
europepmc   +1 more source

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

MRI findings consistent with sacrococcygeal osteomyelitis temporally associated with ultrasound-guided caudal epidural steroid injection: A case report. [PDF]

Interv Pain Med
Erten M, Onurmen-Zeyrek O, Isik R, Dogan T, Nas K.   +4 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain. [PDF]

Eur J Pain
Blechschmidt V, Schlickenrieder B, Husk JR, Hoheisel U, Mörz H, Treede RD, Greffrath W.   +6 more
europepmc   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

De-implementing spinal injections in pursuit of value-based care: Rethinking pain relief. [PDF]

J Pain
Ballengee LA, Lentz TA, Goertz C, McStay F, Morken I, George SZ.   +5 more
europepmc   +1 more source

Simultaneous pneumocephalus and meningitis as a complication of ozone therapy. [PDF]

North Clin Istanb
Dal SE.
europepmc   +1 more source

Anatomy of Cerebro-cerebellar Circuits in Motor Control. [PDF]

Cerebellum
Ruigrok TJH, Gao Z.
europepmc   +1 more source