Results 181 to 190 of about 372,177 (293)

Case Report: Pasireotide treatment in neonatal congenital hyperinsulinism due to a homozygous <i>ABCC8</i> mutation. [PDF]

Front Endocrinol (Lausanne)
Kurz C, Roeper M, Friesl L, Mayatepek E, Meissner T, Kummer S, Hoermann H, Welters A.   +7 more
europepmc   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Introduction to virtual special issue on glucagon-like peptide-1 agonists and the skin. [PDF]

JAAD Case Rep
Levin NA.
europepmc   +1 more source

Subcutaneous Injection of Ergotine in Haemoptysis [PDF]

BMJ, 1871
openaire   +2 more sources

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Acceptability and tolerability of risankizumab maintenance therapy administered via on-body injector in patients with Crohn's disease: Results of the ACCEPT-OBI study. [PDF]

Ther Adv Gastroenterol
Buisson A, Gebara K, Caron B, Boschetti G, Gilletta de Saint Joseph C, Nachury M, Brixi H, Juillerat P, Serrero M, Vuitton L, Hebuterne X, Caillo L, Blain A, Laharie D, Peyrin-Biroulet L, Altwegg R, Le Cosquer G, Pereira B, Fumery M.   +18 more
europepmc   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Use of Liquid Platelet-Rich Fibrin (Liquid PRF) as a New, Effective Regenerative Treatment for Steroid-Induced Subcutaneous and Dermal Atrophy. [PDF]

Cureus
Aalami Harandi S, Saadat S, Miron RJ, Farshidfar N, Balighi K.   +4 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Teriparatide Therapy in Children with Hypoparathyroidism: A Systematic Review and Meta-Analysis. [PDF]

Calcif Tissue Int
Tantivit N, Punyawatthananukool S.
europepmc   +1 more source