Results 211 to 220 of about 139,229 (304)

Subcutaneously Administered Tislelizumab in Locally Advanced or Metastatic Non-Small Cell Lung Cancer: Pharmacokinetics and Safety Results from the BGB-A317-103 Phase I Study. [PDF]

Clin Cancer Res
Chen M, Bulat I, Maglakelidze M, Li N, Chen Z, Kong W, Li Y, Fang J, Zhang J, Zhang J, Wang B, Ma J, Sun Y, Wang Q, Chen X, Liu X, Yu T, Hanley WD, Budha N, Li H, Lin X, Niu Z, Jamal L, Abdrashitov R, Wang M.   +24 more
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Subcutaneous Medicaments Administration in Nursing Practice

Bakalářská práce se zaměřuje na postup podání subkutánních injekcí ve vybraném zdravotnickém zařízení. Teoretická část se zabývá doporučeními k aplikaci subkutánních injekcí, zejména pak k aplikací inzulinů a nízkomolekulárních heparinů.
Rašová, Kristýna
core  

GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice. [PDF]

Nature
Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao XB, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD.   +52 more
europepmc   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Sweet relief: the role of glucopuncture in neuropathic pain management. [PDF]

Korean J Pain
Chang M, Nahm FS, Choi EJ.
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Overview of the Current Osteoarthritis Treatment in Veterinary Medicine and Future Directions. [PDF]

ACS Pharmacol Transl Sci
Quintão NLM, Moffa EB, Kroier M, Goldoni RC, Bundgaard L, Jensen AL, Fernandes ES.   +6 more
europepmc   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Efficacy and Safety of a Poly-L-Lactic Acid Filler for Temporal Augmentation: A Randomized, No-treatment Control, Evaluator-blinded, Multicenter Study. [PDF]

Aesthet Surg J
Chang G, Tan Z, Ting W, Bi H, Wang H, Zhang A, Yu N, Long X.   +7 more
europepmc   +1 more source