Results 21 to 30 of about 14,925 (261)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Structural Optimization of the Venturi Fertilizer Applicator Using Head Loss Calculation Methods

Fluids
Fertilizer suction flow rate is an important performance parameter of the Venturi fertilizer applicator. This study aims to analyze the optimal structure of the Venturi fertilizer applicator with the goal of maximizing the suction flow rate at the same ...
Zhiyang Zhang, Yang Li, Juling Gao, Pan Tang, Feng Huang   +4 more
doaj   +1 more source

Modelling of Hydroabrasive Erosion in Pelton Turbine Injector

International Journal of Rotating Machinery, 2022
Sand particle-led erosion in the turbine parts of hydropower projects (excluding storage type projects) based on Himalaya-originated Rivers is one of the key operational challenges for concerned hydropower stations.
Tri Ratna Bajracharya, Rajendra Shrestha, Anil Sapkota, Ashesh Babu Timilsina   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Piston Crown Profile Modifications for Various Combustion Mode Strategies of Modified GDI Engine towards NOx and PM Reduction

International Journal of Automotive Science and Technology, 2020
In the current development of automotive engines, the major target is to design a combustion chamber in such a way that the combustion process must provide very less concentrations of emissions. To satisfy current worldwide emission norms, petrol engines
Shiva Kumar
doaj   +1 more source

Macroscopic Parameters of Fuel Sprays Injected in an Optical Reciprocating Single-Cylinder Engine: An Approximation by Means of Visualization with Schlieren Technique

Sensors, 2023
This paper proposes a sensor system for an internal combustion engine based on a new vision-based algorithm supported by the Schlieren sensorization technique, which allows to acquire the macroscopic parameters of the fuel spray injected in a ...
Lis Corral-Gómez, Fernando J. Castillo-García, José A. Soriano, Octavio Armas   +3 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Optimization Design of Drive Mode of Coiled Tubing Injector Head

Shiyou jixie, 2017
At present, there are some defects in the actual use of coiled tubing injector head drive method. In order to address these defects and improve the performance of the injector head, focusing on the structural characteristics of the injector head and ...
Duan Wenyi, Liu Pingguo, Liu Fei, Ma Qing, Hao Jun, Hu Zhiqiang   +5 more
doaj  

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source