Results 41 to 50 of about 1,228,997 (292)
FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs +7 more
wiley +1 more source
Oregon Head Start Association Newsletter issue: November 2011 [PDF]
, 2011 November 2011 issue of the Oregon Head Start Association Newsletter. Included in the issue is a story about the Community Action Head Start program in Washington County. This is from the records of the Washington County Community Action Organization, an
Oregon Head Start Association
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera +20 more
wiley +1 more source
Research on Gripping Performance of CT Injector Head Gripper Block and Structure Optimization
Shiyou jixie, 2019 The gripper block is the core component of the coiled tubing (CT) injector head and has a crucial influence on the overall reliability of the injector head.
Hu Zhiqiang +5 more
doaj
Experimental Study of the Swirling Oxidizer Flow in HTPB/N2O Hybrid Rocket Motor
International Journal of Aerospace Engineering, 2017 Effects of swirling oxidizer flow on the performance of a HTPB/N2O Hybrid rocket motor were studied. A hybrid propulsion laboratory has been developed, to characterize internal ballistics characteristics of swirl flow hybrid motors and to define the ...
Mohammad Mahdi Heydari +1 more
doaj +1 more source
, 1968 A high number of liquid oxygen and gaseous hydrogen orifices per unit area are provided in an injector head designed to give intimate mixing and more thorough combustion.
Green, C. W., Jr.
core
Virtual Tumor Boards for Remote Learning in Head and Neck Surgical Oncology
, 2023 Importance: In addition to their patient management value, multidisciplinary tumor boards have been recognized as effective learning tools. However, the value of using a virtual tumor board as a learning tool for head and neck surgical oncology fellows ...
Babak Givi +13 more
core +1 more source
Stage‐Specific Patterns of Imaging and Non‐Motor Biomarkers in Spinocerebellar Ataxia Type 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Advancements in disease‐modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non‐motor and imaging‐based features across different disease stages.
Chun Li +17 more
wiley +1 more source