Results 51 to 60 of about 2,384,246 (269)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Establishing an injury indicator for severe paediatric injury [PDF]

Injury Prevention, 2015
BackgroundRoutinely gathered injury data, such as hospitalisations, may be subject to variation from sources other than injury incidence. There is a need for an indicator that defines severe injury, which may be less vulnerable to fluctuations due to changes in care policies.
Ian, Pike, Mina, Khalil, Natalie L, Yanchar, Hala, Tamim, Avery B, Nathens, Alison K, Macpherson   +5 more
openaire   +3 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mixed reality–assisted navigation versus conventional manual positioning for anterior cruciate ligament reconstruction using 3D-printed knee models: a controlled experimental study

Journal of Orthopaedic Surgery and Research
Purpose To evaluate the effects of mixed reality (MR)–assisted navigation compared with conventional manual positioning on operative time and tunnel positioning accuracy during anterior cruciate ligament reconstruction (ACLR) using 3D-printed knee models.
Binyang Meng, Zi Zhang, Wenhe Li, Baoting Li, Yichen Wang, Hao Pang, Zhilin Yue, Rui Wang, Qi Wang, Jiangang Cao   +9 more
doaj   +1 more source

Medical care-seeking behaviours among drowning casualties: Results from a national survey conducted in Bangladesh

Journal of Taibah University Medical Sciences, 2020
الملخص: أهداف البحث: على الرغم من الانتشار المتزايد للغرق، فإن سلوكيات البحث عن الرعاية الطبية بين ضحايا الغرق لا تزال غير مستكشفة في بنغلاديش. تهدف هذه الدراسة إلى استكشاف سلوكيات البحث عن الرعاية الطبية بين ضحايا الغرق في بنغلاديش.
Mohammad J. Hossain, MPH, Md S. Hossain, MPH, Al-Amin Bhuiyan, PhD, AKM F. Rahman, PhD, Saidur R. Mashrelky, PhD, Aminur Rahman, PhD   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effect of bilateral upper limb training after priming upper limb robot training on upper limb function in stroke patients with severe hemiplegia

Zhongguo kangfu lilun yu shijian
Objective To compare the effect between unilateral and bilateral upper limb training on motor function of severely hemiplegic upper limbs in subacute stroke patients after priming robot-assisted training.
HE Aiqun, LI Jingbo, LIU Hai'ou, SONG Qiushuang, HE Maoli, LIN Rumin   +5 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Baseline level of interleukin-6 is associated with the risk of acute coronary syndrome development in SARS-CoV‐2 infection

BMC Cardiovascular Disorders
Background Acute coronary syndrome (ACS) is frequently reported in patients with coronavirus disease 2019 (COVID-19). Cytokine storm induced by interleukin-6 (IL-6) has been suggested to potentially cause myocardial injury in COVID-19.
Mohsen Sedighi, Mohammad Hasan Shahabi, Maryam Akbarpour, Alireza Amanollahi, Nader Tavakoli, Aydin Mohammad Valipour, Hamed Basir Ghafouri   +6 more
doaj   +1 more source