Results 61 to 70 of about 1,870,639 (308)

Discerning Disparities: The Data Gap

open access: yesAmerican Journal of Men's Health, 2019
Health disparities that focus on gender and on the ancillary dependent variables of race and ethnicity reflect continually early illness, compromised quality of life, and often premature and preventable deaths.
Henrie M. Treadwell PhD   +4 more
doaj   +1 more source

On-field player workload exposure and knee injury risk monitoring via deep learning

open access: yes, 2019
In sports analytics, an understanding of accurate on-field 3D knee joint moments (KJM) could provide an early warning system for athlete workload exposure and knee injury risk.
Alderson, Jacqueline A.   +3 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Trends in prevalence of coexistence of hypertension and diabetes mellitus among residents aged 35 – 74 years in Shanghai, 2002 – 2017: a surveillance data analysis

open access: yesZhongguo gonggong weisheng
ObjectiveTo estimate the trend in the coexistence of hypertension and diabetes mellitus (HTN-DM) among residents aged 35 – 74 years in Shanghai during 2002 – 2017 for the prevention and control of the comorbidity.MethodsThe study data were from four ...
Ke CAO   +9 more
doaj   +1 more source

Assessment of Pulmonary Vascular Injury

open access: yesJournal of Investigative Surgery, 1992
The assessment of pulmonary injury in experimental and clinical situations remains a challenge. A method of quantifying pulmonary vascular aberrations in animal models and human clinical situations is described. A multiple-indicator dilution technique is employed to assess changes in lung capillary permeability--surface area product, extravascular lung
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

The principles of experimental traumatic brain injury modelling

open access: yesUkrainian Neurosurgical Journal, 2008
The contemporary approaches to traumatic brain injury modeling, the principles of functioning and technical characteristics of appropriate equipment are reviewed.
V. V. Biloshytsky
doaj   +1 more source

Differential neuroproteomic and systems biology analysis of spinal cord injury [PDF]

open access: yes, 2016
Acute spinal cord injury (SCI) is a devastating condition with many consequences and no known effective treatment. Although it is quite easy to diagnose traumatic SCI, the assessment of injury severity and projection of disease progression or recovery ...
Bramlett, Helen M   +8 more
core   +2 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

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