Results 41 to 50 of about 651,306 (267)

Quality of life in road traffic accident survivors

open access: yesSlovenian Journal of Public Health, 2020
The loss of quality of life is the major consequence following a non-fatal road traffic accident (RTA). Previous research regarding quality of life did not include uninjured RTA survivors.
Kovačević Jelena   +9 more
doaj   +1 more source

Severe penile injuries: a problem of severity and reconstruction [PDF]

open access: yesBJU International, 2009
OBJECTIVES To report our experience of treating severe penile injuries with different causes and treatments, as penile trauma presents a difficult physical and psychological problem, and the type and extent of injury varies from mild to severe, sometimes even with total amputation.
Sava V, Perovic   +5 more
openaire   +2 more sources

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Identifying the key risk factors of traffic accident injury severity on Slovenian roads using a non-parametric classification tree

open access: yesTransport, 2017
From both a practical and economic point of view, road transport meets almost all the requirements of modern life, but it is also a source of numerous negative effects, including traffic accidents.
Vesna Rovšek   +2 more
doaj   +1 more source

Severe soccer injuries in amateurs [PDF]

open access: yesBritish Journal of Sports Medicine, 2003
Objectives:To ascertain the number and type of severe soccer injuries admitted to King Edward Hospital in South Africa over 42 months.Methods:This was a retrospective study of all patients admitted for treatment or observation to the orthopaedic unit only.
I E, Goga, P, Gongal
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Leukocytosis as a Predictor of Severe Injury in Blunt Trauma

open access: yesWestern Journal of Emergency Medicine, 2008
Objective: The objective of this study was to determine if the white blood cell count can predict severity of injury in blunt trauma victims.Methods: This was a retrospective study comparing two groups of blunt trauma victims by severity of injury, one ...
Santucci, Claudia A   +2 more
doaj  

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