Results 51 to 60 of about 651,306 (267)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Correlating Various Clinical Outcomes and Associated Dispositions in Patients with Severe Traumatic Brain Injury (TBI)

Life
Background: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Patient disposition following TBI has been shown to interact with factors such as age, sex, and injury severity to impact clinical outcomes.
Bharti Sharma, Tirth Patel, Sarah Dawson-Moroz, George Agriantonis, Munirah Hasan, Navin D. Bhatia, Carrie Garcia, Praise Nesamony, Jasmine Dave, Juan Mestre, Shalini Arora, Saad Bhatti, Zahra Shafaee, Suganda Phalakornkul, Kate Twelker, Jennifer Whittington   +15 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Truck-involved crash severity in Thailand: a multilevel perspective on driver behavior and contextual influences

Frontiers in Built Environment
Truck-involved crashes in Thailand frequently lead to severe consequences due to the vehicles’ large size, heavy loads, and high-speed operations.
Supanida Nanthawong, Panuwat Wisutwattanasak, Chinnakrit Banyong, Adisorn Dangbut, Thanapong Champahom, Vatanavongs Ratanavaraha, Sajjakaj Jomnonkwao   +6 more
doaj   +1 more source

SEVERE INJURY OF THE THIGH. [PDF]

The Lancet
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openaire   +2 more sources

Severe Traumatic Brain Injury [PDF]

Neurosurgery, 2017
Background: Inadvertent hyperventilation is associated with poor outcomes from traumatic brain injury (TBI). Hypocapnic cerebral vasoconstriction is well described and causes an immediate and profound decrease in cerebral perfusion. The hemodynamic effects of positive-pressure ventilation (PPV) remain incompletely understood but may be equally ...
David L, Penn, John H, Chi, Mark R, Proctor   +2 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Severe radiation injuries of the lung [PDF]

American Journal of Roentgenology, 1977
The lung is a radiosensitive organ whose limited tolerance must be treated with great respect in the radiation management of malignant tumors in the thorax. Severe radiation pneumonopathy can cripple and kill as the outcome of faulty judgment, error, accident, or calculated risk in an effort to control a locally advanced cancer.
B, Roswit, D C, White
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Exploring Factors Influencing Injury Severity of Bicyclists in Crashes with Motor Vehicles – Combined Latent Class Clustering and MNL Model

Promet (Zagreb)
With the increase in travel costs brought about by motor vehicles and the enhancement of environmental awareness among travellers, the rise in bicycle usage has grown globally.
Peikun LI, Jingyu DING, Quantao YANG, Wenbo LU   +3 more
doaj   +1 more source