Results 81 to 90 of about 1,139,502 (291)

AOSpine—Spine Trauma Classification System: The Value of Modifiers: A Narrative Review With Commentary on Evolving Descriptive Principles [PDF]

, 2019
Study Design: Narrative review. Objectives: To describe the current AOSpine Trauma Classification system for spinal trauma and highlight the value of patient-specific modifiers for facilitating communication and nuances in treatment.
Benneker, MD, Lorin M., Chapman, MD, Jens R., Divi, MD, Srikanth N., Dvorak, MD, Marcel F., Kandziora, MD, PhD, Frank, Oner, MD, PhD, Cumhur, Schnake, MD, Klaus J., Schroeder, MD, Gregory D., Vaccaro, MD, PhD, MBA, Alex R.   +8 more
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Single-vehicle injury crashes on rural roads in Iceland: contribution of unforgiving roadsides to fatal and serious injuries of vehicle occupants

Traffic Safety Research
About 50% of the most severe crashes on rural roads in Iceland are run-off-road crashes. Many existing roads were designed before the concept of forgiving roadsides became prevailing in road design in Iceland.
Audur Thora Arnadottir, Gudmundur F. Ulfarsson, Sungyop Kim   +2 more
doaj   +1 more source

Evaluation of the test–retest repeatability of the Injury Severity Perception score in patients with acute whiplash-associated disorder

Journal of Sport and Health Science, 2015
Objective: To determine the test–retest repeatability of the Injury Severity Perception (ISP) score in participants with acute whiplash-associated disorders (WADs).
Robert Ferrari
doaj   +1 more source

Diverging volumetric trajectories following pediatric traumatic brain injury. [PDF]

, 2017
Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development.
Asarnow, Robert F, Babbitt, Christopher, Babikian, Talin, Dennis, Emily L, Faskowitz, Joshua, Giza, Christopher C, Jahanshad, Neda, Johnson, Jeffrey, Mink, Richard, Rashid, Faisal, Thompson, Paul M   +10 more
core   +3 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Gender Differences in DUI Crash Injury Severity: A Partially Constrained Random-Parameter Logit Model Analysis

Applied Sciences
Driving under the influence (DUI) has long been recognized as a major contributor to traffic accidents. However, the factors influencing the severity of crashes in DUI situations may vary significantly between genders due to physiological and ...
Yanqun Yang, Zhendong Huang, Said M. Easa, Ibrahim El-Dimeery, Wei Lin   +4 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Modeling healthcare demands and long-term costs following pediatric traumatic brain injury

Frontiers in Neurology
IntroductionTraumatic brain injury (TBI) is a leading cause of death and disability in children, but data on the longitudinal healthcare and financial needs of pediatric patients is limited in scope and duration.
Jared G. Wiegand, Zorays Moazzam, Bruno P. Braga, Bruno P. Braga, Sarah E. Messiah, Sarah E. Messiah, Sarah E. Messiah, Faisal G. Qureshi, Faisal G. Qureshi   +8 more
doaj   +1 more source