Results 1 to 10 of about 10,963 (143)

Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2 [PDF]

Revista de la Facultad de Ciencias Médicas de Córdoba, 2022
Introducción: La infección emergente producida por el nuevo coronavirus SARS-CoV-2, se ha constituido en un verdadero desafío para la comunidad científica.
Emanuel Bottino, Andrés Alberto Ponce
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Combined glyphosate and chlorpyrifos-based pesticides impair innate and adaptive immune functions: an in vitro approach [PDF]

Environmental Health
Background The widespread use of pesticides, including glyphosate-based herbicides (e.g., Roundup®, R) and chlorpyrifos-based insecticides (e.g., Clorpi48®, C), has raised concerns about their environmental and human health impacts.
Adrián David Friedrich, Daniela Belén Gareis, María Eugenia Ordoñez, María Victoria Regge, María Cecilia Santilli, María Natalia Rubinsztain, Mariana Gantov, María Sofía Amarilla, María Eugenia Gaillardou, Carolina Ines Domaica, Mercedes Beatriz Fuertes, Norberto Walter Zwirner   +11 more
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What immunology has to say about pesticide safety [PDF]

Frontiers in Immunology
The use of pesticides has enabled the development of contemporary industrial agriculture and significantly increased crop yields. However, they are also considered a source of environmental pollution and a potential hazard to human health.
Adrián David Friedrich, Norberto Walter Zwirner, Norberto Walter Zwirner   +2 more
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Author Correction: Bile acids attenuate PKM2 pathway activation in proinflammatory microglia [PDF]

Scientific Reports, 2022
Lorenzo Romero-Ramírez, Concepción García-Rama, Siyu Wu, Jörg Mey   +3 more
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Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1

Frontiers in Immunology, 2021
Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional.
Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Nuñez, Nicolás Ignacio Torres, Florencia Secchiari, Jessica Mariel Sierra, Raúl Germán Spallanzani, Agustín Rovegno, Fernando Pablo Secin, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner, Norberto Walter Zwirner   +12 more
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Bile acids attenuate PKM2 pathway activation in proinflammatory microglia

Scientific Reports, 2022
Glycolysis is the metabolic pathway that converts glucose into pyruvate. Central nervous system (CNS) pathologies, such as spinal cord injury (SCI) and ischemia, are accompanied by an increase of the glycolytic pathway in the damaged areas as part of the
Lorenzo Romero-Ramírez, Concepción García-Rama, Siyu Wu, Jörg Mey   +3 more
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The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology

OncoImmunology, 2022
NKG2D is a major natural killer (NK) cell-activating receptor that recognizes eight ligands (NKG2DLs), including MICA, and whose engagement triggers NK cell effector functions.
Florencia Secchiari, Sol Yanel Nuñez, Jessica Mariel Sierra, Andrea Ziblat, María Victoria Regge, Ximena Lucía Raffo Iraolagoitia, Agustín Rovegno, Carlos Ameri, Fernando Pablo Secin, Nicolás Richards, Hernando Ríos Pita, Gonzalo Vitagliano, Luis Rico, Mauro Mieggi, Florencia Frascheri, Nicolás Bonanno, Leandro Blas, Aldana Trotta, Adrián David Friedrich, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner   +21 more
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Leveraging NKG2D Ligands in Immuno-Oncology

Frontiers in Immunology, 2021
Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened new avenues towards the development of novel assets to achieve durable immune control of cancer.
Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner, Norberto Walter Zwirner   +3 more
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Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation

Frontiers in Immunology, 2021
Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions.
Jessica M. Sierra, Florencia Secchiari, Sol Y. Nuñez, Ximena L. Raffo Iraolagoitia, Andrea Ziblat, Adrián D. Friedrich, Adrián D. Friedrich, María V. Regge, M. Cecilia Santilli, Nicolás I. Torres, Mariana Gantov, Aldana Trotta, Carlos Ameri, Gonzalo Vitagliano, Hernando Ríos Pita, Luis Rico, Agustín Rovegno, Nicolás Richards, Carolina I. Domaica, Norberto W. Zwirner, Norberto W. Zwirner, Mercedes B. Fuertes   +21 more
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Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein

Journal for ImmunoTherapy of Cancer, 2020
Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA and ...
Kenneth W Hance, Nicolas Torres, María Victoria Regge, Florencia Secchiari, Adrián David Friedrich, Raúl Germán Spallanzani, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Núñez, Jessica Mariel Sierra, Andrea Ziblat, María Cecilia Santilli, Nicolás Gilio, Evangelina Almada, Constanza Lauche, Romina Pardo, Carolina Inés Domaica, Mercedes Beatriz Fuertes, Kevin Patrick Madauss, Israel S Gloger, Vanesa Zylberman, Fernando Alberto Goldbaum, Norberto Walter Zwirner   +21 more
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