Results 31 to 40 of about 43,554 (263)

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

The Components of the Glacial Runoff of the Tsambagarav Massif from Stable Water Isotope Data

Geosciences, 2019
The aim of this study was to determine the contribution of snow and glacial ice to the river fluxes, and to identify the type of ice formation in the Tsambagarav massif (the northwestern part of Mongolia).
Dmitry V. Bantcev, Dmitry A. Ganyushkin, Kirill V. Chistyakov, Ilya V. Volkov, Alexey A. Ekaykin, Arina N. Veres, Igor V. Tokarev, Natalya B. Shtykova, Tatiana A. Andreeva   +8 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Distribution patterns of the Baraba buzzing grasshopper Angaracris barabensis (Pallas) (Orthoptera: Acrididae)

Юг России: экология, развитие
Aim. Angaracris barabensis is widely distributed across the Asian grasslands. It is often qualified as one of the important pests. The aim of the paper is to estimate possible shifts of its distribution relative to global warming.
A. I. Pashkova, V. V. Molodtsov, S. Yu. Storozhenko, N. S. Baturina, K. V. Popova, O. V. Yefremova, M. G. Sergeev   +6 more
doaj   +1 more source

Territorialising Chinese Inner Asia: The Neo-Developmentalist State and Minority Unrest

International Quarterly for Asian Studies, 2019
Despite the Chinese Communist Party’s claim to inter-ethnic harmony, the human rights situation of some of the PRC’s 55 official minorities is problematic.
Sören Köpke
doaj   +1 more source

Recent decrease in inner‐core rain rate of tropical cyclones over the western North Pacific

Atmospheric Science Letters, 2022
The tendency in tropical cyclone (TC) rainfall is of great concern due to its remarkable contribution to global precipitation and extreme rainfall events. This study finds a decreasing trend in TC inner‐core rain rate over the western North Pacific (WNP)
Na Wei, Jinjie Song, Yifei Dai, Sulin Jiang, Yihong Duan   +4 more
doaj   +1 more source

Groundwater Rise Sustains the World's Largest Alpine Water System Under Global Warming

Advanced Science, EarlyView.
Shallow groundwater depth (SGWD) across the non‐permafrost plains of the Qinghai–Xizang Plateau decreased at averagely 0.02 m year−1, adding 31.44 Gt of freshwater storage from 2000 to 2020 and sustaining ∼53 500 km2 of alpine ecosystems. A vadose‐zone capacity of 426.6 Gt reveals these aquifers as promising reservoirs, highlighting groundwater's ...
Jianqing Du, Zhixiang Niu, Yanfen Wang, Shirui Zhou, Youqing Yang, Xiang Wei, Haishan Niu, Yitao Zhang, Anquan Xia, Yali Liu, Yanbin Hao, Kai Xue, Bingfang Wu, Xinquan Zhao, Tandong Yao, Yiyu Chen   +15 more
wiley   +1 more source

Two new species of Tropodiaptomus Kiefer, 1932 (Copepoda, Calanoida, Diaptomidae) from temporary waters in Thailand and Cambodia with a key to Southeast Asian species [PDF]

ZooKeys
Two new copepod species of the species-rich genus Tropodiaptomus, collected from temporary water habitats in Southeast Asia, are described. A critical morphological comparison has revealed that the two new species, T. lannaensis sp. nov.
Kamonwan Koompoot, Laorsri Sanoamuang
doaj   +3 more sources

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source