Results 61 to 70 of about 12,531 (316)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

The Queer Child in the Nuevo Cine Español

open access: yesInterAlia, 2017
The Nuevo Cine Español often employed the gaze of children as an effective strategy to show the traumatic effects of events such as the Civil War and Francoism on the Spanish society. Spanish film critics considered children apt figures to be constructed
Jorge Pérez
doaj   +1 more source

Pretpostavka nevinosti okrivljenog kao element prava na pravično suđenje [PDF]

open access: yesRevija za kriminologiju i krivično pravo
Although the presumption of innocence has its roots in the rational criminal procedure of the ancient times, it should still be seen as a result of the modern criminal procedure system, i.e.
Drago Radulović
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

The silence of innocence

open access: yesArchives of Pediatric Neurosurgery, 2021
The mysterious and suspicious death of the young Henry Borel on March 8, 2021 in Brazil brought up again the subject of child violence to the media. The child had multiple injuries in the abdominal cavity, pulmonary contusion, head trauma and other injuries incompatible with a domestic accident or fall in his room as reported by parents.
openaire   +4 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

"عصمتِ أنبیاء سے بظاہر متعارض صحیحین کی بعض أحادیث کا علمی جائزہ Analysis of some apparently conflicting Ahâdith of Sahihyain on Ismat Anbiân"

open access: yesالإيضاح, 2018
Prophets and Messengers have the holiest status amongst Allah’s creation. They are the caliph of Allah in the world. Allah’s characteristics which can be present in a human after Him are present in Prophets and Messengers.
ڈاکٹرمفتی محمد التماس خان   +1 more
doaj  

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