Results 131 to 140 of about 1,071,283 (270)

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

Chlorella sp. inoculum doses affect ethinylestradiol removal in a wastewater treatment plant in the Peruvian Andes

Acta Scientiarum: Technology
The microalgae Chlorella sp. have demonstrated efficiency in the removal of pharmaceutical contaminants. However, there is no agreement on the inoculum dose since it depends on the contaminant concentration and other very specific parameters in each ...
Azucena Chavez Collantes, Richard Andi Solórzano Acosta, Leslie Diana Velarde Apaza, Joseph Campos Ruiz, Edin Edgardo Alva Plasencia, Eisner Will Castillo Rojas   +5 more
doaj   +1 more source

Eficiencia e innovación para el éxito de las empresas tradicionales: El caso del grupo

Revista Galega de Economía, 2014
Este artículo describe cómo las empresas establecidas en industrias tradicionales pueden tener éxito en pre-sencia de discontinuidades. Este estudio sugiere que para sobrevivir y seguir creciendo continuamente es necesario que los directivos equilibren en sus empresas los modelos de exploración y de explotación.
openaire   +1 more source

Applying model-driven paradigm: CALIPSOneo experience [PDF]

, 2013
Model-Driven Engineering paradigm is being used by the research community in the last years, obtaining suitable results. However, there are few practical experiences in the enterprise field. This paper presents the use of this paradigm in an aeronautical
Escalona Cuaresma, María José, García García, Julián Alberto, Mas, Fernando, Oliva, Manuel, Valle Sevillano, Carmelo del   +4 more
core  

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

The microeconomics of water demand under deficit irrigation: a case study in Southern Spain [PDF]

, 2017
This contribution presents an exploratory analysis of the microeconomics of deficit irrigation (DI) as a technique with growing prevalence in water scarce areas, as it is the case of southern Spain.
Berbel Vecino, Julio, Expósito García, Alfonso   +1 more
core  

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Innovación en modelos de negocio: La Base de la Pirámide como campo de experimentación

Revista Galega de Economía, 2014
Los modelos de negocio en los mercados de renta baja brindan grandes oportunidades para desarrollar soluciones innovadoras que colaboren efectivamente con la reducción de pobreza y generen capacidades, y productos que mejoren la competitividad de la empresa.
openaire   +1 more source

Coupled Above‐ and Belowground Ecosystem Stability Worldwide

Advanced Science, EarlyView.
Are the worlds above and below our feet in sync? This global exploration reveals an entangled fate between above‐ and belowground ecosystem stability. It identifies arid regions as hotspots for this coupling and highlights temperature stability as a vital safeguard for maintaining ecosystem balance across our warming planet.
Zexin Meng, Huiwen Li, Yiping Wu, Peter B. Reich, Nico Eisenhauer, Diego Abalos, Daniel Revillini, Shuguang Liu, Wende Yan, Ji Chen, Alexey Voinov, Zhifeng Yang, Ying‐Ping Wang, Fubo Zhao, Linjing Qiu, Jingfeng Xiao, Shantao An, Guopeng Liang, Manuel Delgado‐Baquerizo   +18 more
wiley   +1 more source

La Ciencia de los Servicios: un nuevo enfoque para la innovación en compañías de servicios

Revista Galega de Economía, 2014
En los últimos meses se está apreciando un notable interés entre diversos actores sociales por un área científica de prometedor futuro: la "Ciencia de los Servicios". Esta nueva disciplina académica y profesional propone dar un enfoque científico-técnico a las tareas que se desarrollan en el sector terciario de la economía.
openaire   +1 more source