A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul+11 more
wiley +1 more source
The Western Rebellion of 1549. (An account of the Insurrections in Devonshire and Cornwall against Religious Innovations in the Reign of Edward VI). Frances Rose-Troup. Smith, Elder, & Co.1913. Pp. xvi, 520. $5.00. [PDF]
Henry Washburn
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Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef+10 more
wiley +1 more source
Sir Thomas Browne, knight; doctor of physick; anti-cromwellian loyalist; witch-finder; amateur exponent of christian doctrine; conservative opponent of scientific innovation; and iconoclastic critic of the errors of the “learned Vulgar,” with their “authorities” [PDF]
John R. Knott
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ENTREPRENEURS CONFIDENCE IN INNOVATION AND THEIR INNOVATIVENESS
This article tests the hypothesis that entrepreneurs confidence in innovation has a positive effect on their innovativeness. The sample is 550 owner managers sampled from the population of owner managers in Iran in 2010, surveyed in the Global Entrepreneurship Monitor, GEM.
Nochian, Nastooh, Schøtt, Thomas
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Media Innovations, User Innovations, Societal Innovations
As the Journal of Media Innovations comes into existence, this article reflects on the first and most obvious question: just what do we mean by “media innovations”? Drawing on the examples of a range of recent innovations in media technologies and practices, initiated by a variety of media audiences, users, professionals, and providers, it explores the
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez+5 more
wiley +1 more source
Incentive Mechanism of R&D Firms’ Collaborative Innovation Based on Organisational Ambidexterity
From the perspective of organizational ambidexterity, we consider the choice of innovation strategy among R&D firms. By building on contractual arrangements and employing a dynamic game model, we focus on the incentive mechanism of R&D Firms ...
Bo Song, Penghao Jin, Liangjie Zhao
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Innovations in apple handling methods and equipment / [PDF]
Earl W. Carlsen
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ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee+9 more
wiley +1 more source