Results 111 to 120 of about 6,801,825 (368)
Rethinking communication in innovation processes: creating space for change in complex systems [PDF]
, 2010 : In innovation studies, communication received explicit attention in the context of studies on the adoption and diffusion of innovation that dominated the field in the 1940-1970 period.
Aarts, M.N.C., Leeuwis, C.
core +1 more source
An Overview of Intelligent Transportation Systems in Europe
World Electric Vehicle JournalThis paper provides a comprehensive review of the development, deployment and challenges of Intelligent Transport Systems (ITSs) in Europe. Driven by the EU Directive 2010/40/EU, the deployment of ITSs has become essential for improving the safety ...
Nicolae Cordoș +4 more
doaj +1 more source
Tejuelo: Didáctica de la Lengua y la Literatura, 2017 Resumen En la sociedad de la información en la que nos encontramos inmersos la proliferación y el auge que están teniendo hoy en día dispositivos como smartphone, tablet, phablet se manifiesta en la asunción de nuevos modelos de aprendizaje, formas ...
Noelia Margarita Moreno Martínez +1 more
doaj +1 more source
Contextualizing Digital Innovation and Artificial Intelligence to Sustainable Development [PDF]
, 2021 Sunil Kumar Mishra, Parul Mishra
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Recognising and rewarding innovation in construction: exploring disconnections in managerial discourse [PDF]
, 2009 The construction industry has often been considered a 'low innovation' sector. This research seeks to understand more deeply the manifestation of innovation at the construction workplace and raises questions as to whether there is really a dearth of ...
Chan, Paul, Littlemore, Michelle
core
, 2009 We seek explanation for how a species with our complex social systems could have arisen. We argue that an “innovation innovation” took place during hominin evolution that decoupled organizational change from a Darwinian evolutionary process and underlies the forms of social organization we find in human societies today.
D. Read +2 more
openaire +3 more sources
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source