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In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen+17 more
wiley +1 more source
Learning curves and collaboration in reconceiving refugee settlements
A collaboration between UNHCR, Ennead Architects and Stanford University uses settlement design to promote innovation and further development in the refugee protection model but collaborators initially face a steep learning curve.
Mariano-Florentino Cuéllar+1 more
doaj
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song+13 more
wiley +1 more source
2011 Strategic roadmap for Australian research infrastructure [PDF]
The 2011 Roadmap articulates the priority research infrastructure areas of a national scale (capability areas) to further develop Australia’s research capacity and improve innovation and research outcomes over the next five to ten years.
Department of Innovation+2 more
core
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda+3 more
wiley +1 more source
UNLV faculty demonstrate that research is actually the mother of invention – although necessity certainly got them ...
Fruth, Laurie
core
The roles and applications of extracellular vesicles in cancer
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley +1 more source
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan+10 more
wiley +1 more source
Breakthrough innovation and incremental innovation have different impacts on economic development. For regional development, it is important to find a balance in dual innovation, which entails effective coordination of allocating innovation resources and
Qingyi Chen, Yuting Liu, Zuolin Yao
doaj +1 more source