Results 51 to 60 of about 5,711,473 (427)

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Automation-driven innovation management? Toward Innovation-Automation-Strategy cycle [PDF]

arXiv, 2021
There is a resurging interest in automation because of rapid progress of machine learning and AI. In our perspective, innovation is not an exemption from their expansion. This situation gives us an opportunity to reflect on a direction of future innovation studies. In this conceptual paper, we propose a framework of innovation process by exploiting the
arxiv  

Puzzles in modern biology. II. Language, cancer and the recursive processes of evolutionary innovation [PDF]

F1000Research 5:2089 (2016), 2016
Human language emerged abruptly. Diverse body forms evolved suddenly. Seed-bearing plants spread rapidly. How do complex evolutionary innovations arise so quickly? Resolving alternative claims remains difficult. The great events of the past happened a long time ago. Cancer provides a model to study evolutionary innovation.
arxiv   +1 more source

Exploratory Innovation, Exploitative Innovation and Peformance: Effects of Organizational Antecedents and Environmental Moderators

Management Sciences, 2006
Research on exploration and exploitation is burgeoning, yet our understanding of the antecedents and consequences of both activities remains rather unclear.
Justin J. P. Jansen, F. V. D. Bosch, H. Volberda   +2 more
semanticscholar   +1 more source

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

FEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri, Haruka Tachibana, Daisuke Kawasaki, Taichi Chisuga, Toma Kashima, Shinya Fushinobu, Fumitaka Kudo, Tadashi Eguchi, Akimasa Miyanaga   +8 more
wiley   +1 more source

Innovative innovation in journalism

Journalism, 2023
Previous studies over the past 23 years have illustrated how the journalistic field has embraced innovative processes. While some of these processes were fully developed at that time, others were still in the process of development or implementation. An ad hoc analysis sheet was designed using innovation categories, where each item is assigned a score
José Sixto-García, Xosé López-García   +1 more
openaire   +2 more sources

Innovation with and without patents [PDF]

arXiv, 2022
A long-standing discussion is to what extent patents can be used to monitor trends in innovation activity. This study quantifies the amount and quality of information about actual innovation contained in the patent system, based on 4,460 Swedish innovations (1970-2015) that have been matched to international patents.
arxiv  

Innovation in tourism: Re-conceptualising and measuring the absorptive capacity of the hotel sector [PDF]

, 2014
Recent reviews of research on innovation in tourism have highlighted a number of weaknesses in the literature. Among these is the limited theorising and empirical investigation of innovative practices by tourism organisations.
Alvesson, Armstrong, Arta, Blunch, Camison, Camisón, Carlborg, Carlisle, Chen, Cohen, Cooper, Decelle, Delmas, Dwyer, Easterby-Smith, Emma Wood, Escribano, Feldman, Flatten, Fogg, Fosfuri, Foss, Gallego, Garvin, Gebauer, Gersick, Guisado-Gonzalez, Hall, Hall, Hansen, Harris, Hau, Helfat, Hertog, Hine, Hjalager, Hjalager, Hoarau, Hogan, Hox, Inkpen, Jansen, Jaworski, Jimenez-Barrionuevo, Katkalo, Keegan, King, Kor, Kostopoulos, Krizaj, Lane, Lane, Lichtenthaler, Mei, Mueller, Nachtigall, Nicolau, Nieves, Orfila-Sintes, Paget, Reich, Rhodri Thomas, Roberts, Salvato, Scott, Shaw, Sorensen, Staber, Sun, Tabachnick, Tejada, Thomas, Todorova, Tseng, Valentina, Van de Ven, Vasudeva, Wales, Weidenfeld, Williams, Xiao, Zahra   +81 more
core   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source