Results 51 to 60 of about 3,176,788 (261)

Connected innovation: an international comparative study that identifies mixed modes of innovation [PDF]

, 2011
This paper offers a new angle on innovation modalities by adopting a recently emerging approach towards identifying innovation typologies via exploratory data analysis techniques with the aim to tease out some underlying latent variables that represent ...
Frenz, Marion, Lambert, R.
core  

Configurational innovation systems – Explaining the slow German heat transition [PDF]

, 2019
In the field of sustainability transitions, temporality has recently received increased attention, specifically with regard to understanding acceleration of transitions.
Raven, R. P.J.M., Wesche, J. P., Negro, S. O., Dütschke, E., Hekkert, M. P., Innovation Studies, Dynamics of Innovation Systems   +6 more
core   +2 more sources

Capability building in fuzzy front end management in a high technology services company

International Journal of Innovation, 2020
The purpose of this paper is to evaluate the adherence between the Fuzzy Front End (FFE)’ enablers, reported in the literature, and its application in the innovation process of a very innovative multinational company of high-tech services.
Claudio Marcos Vigna, Abraham Sin Oih Yu, Paulo Tromboni Nascimento, Edison Fernandes Polo, Ana Maria Gati   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ágil fake

International Journal of Innovation, 2020
Objetivo do estudo: A agilidade provoca mudanças estruturais nas empresas, como: na cultura organizacional, na forma de pensar das pessoas, nos processos, papéis, responsabilidades e comportamentos. Para este processo, damos o nome de transformação ágil,
Nadia Pedrosa, Maria Heloiza Rodrigues Magrin, Luciano Ferreira da Silva, Cristina Dai Prá Martens   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Fatores críticos de sucesso da rede de incubação de empreendimentos do IFES

International Journal of Innovation, 2020
Este trabalho intitulado “Fatores Críticos de Sucesso da Rede de Incubação de Empreendimentos do Ifes.” tem como principal objetivo identificar os fatores críticos de sucesso da referida rede de incubação do Ifes, para tanto foi realizado um estudo de ...
João Paulo Carmo, Rodolpho da Cruz Rangel   +1 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Branching innovation, recombinant innovation, and endogenous technological transitions [PDF]

, 2012
We propose a model of technological transitions based on two different types of innovations. Branching innovations refer to technological improvements along a particular path, while recombinant innovations represent fusions of multiple paths. Recombinant
Izquierdo, L.R., Zeppini, Paolo, Frenken, K., Frenken, Koen, Zeppini, P Paolo, Frenken, K Koen, Izquierdo, LR, Innovation Studies, Izquierdo, Luis, Dynamics of Innovation Systems, Izquierdo, L., Zeppini, P.   +11 more
core   +2 more sources