Results 61 to 70 of about 2,891,562 (358)
Sticky Information and the Locus of Problem Solving: Implications for Innovation
, 1994 To solve a problem, needed information and problem-solving capabilities must be brought together. Often the information used in technical problem solving is costly to acquire, transfer, and use in a new location-is, in our terms, "sticky." In this paper ...
E. Hippel
semanticscholar +1 more source
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Resettlement and livelihoods innovation in the US
Forced Migration Review, 2014 Conversations with multiple stakeholders in the US help to highlight barriers to economic self-sufficiency for resettled refugees and opportunities for innovative approaches.
Faith Nibbs
doaj
PLOS ONE, 2020 Predicting innovation is a peculiar problem in data science. Following its definition, an innovation is always a never-seen-before event, leaving no room for traditional supervised learning approaches. Here we propose a strategy to address the problem in the context of innovative patents, by defining innovations as never-seen-before associations of ...
Tacchella +5 more
openaire +6 more sources
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Introduction: refugees and innovation
Forced Migration Review, 2014 Doing innovation well presents challenges for how we can work better together as organisations and with displaced people, and how we can break down traditional barriers between actors – all while upholding ethical principles and protection standards ...
Alexander Betts
doaj
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Innovation and refugee livelihoods: a historical perspective
Forced Migration Review, 2014 It is difficult to speak convincingly of ‘new’ or innovative practices towards refugees, especially in refugee livelihoods assistance, while there remains a significant gap in historical knowledge and institutional memory.
Evan Elise Easton-Calabria
doaj