Results 61 to 70 of about 5,165,706 (279)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Innovation for equity in Lebanon
Forced Migration Review, 2014 Innovative approaches in Lebanon aim to address, in two very different ways, the particular needs of the most vulnerable among the refugee and host populations.
Luciano Calestini
doaj
Regional economic activity report 2014 [PDF]
Provides consistent information for each of New Zealand’s 16 regions. This allows us to compare the regions’ economic performance, distinguish their attributes and specialisations, and understand the different roles they play in the New Zealand
Innovation and Employment (New Zealand) +1 more
core
Innovation brokers and their roles in value chain-network innovation: preliminary findings and a research agenda [PDF]
, 2010 Intervention approaches have been implemented in developing countries to enhance farmer's livelihoods through improving their linkages to markets and inclusiveness in agricultural value chains.
Klerkx, L.W.A. +2 more
core +2 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Technology, production and partnership innovation in Uganda
Forced Migration Review, 2014 Since 2007 a partnership between UNHCR, the Government of Uganda and ‘MakaPads’ inventor Moses Musaazi has helped provide affordable sanitary pads for thousands of refugee girls and women while substantially reducing UNHCR’s expenditure on these ...
Moses Musaazi
doaj
Gender and innovation strategy in crowdfunding
, 2022 James Bort, Azzurra Meoli
openalex +2 more sources
The Small Business Sector report 2014 [PDF]
The Small Business Sector Report 2014 is a government publication that provides a factual source of information in an accessible format on the small businesses that make up a large part of the New Zealand economy. New Zealand needs to encourage firms of
Innovation and Employment (New Zealand) +1 more
core
The prescriptive quality of 11 design principles for knowledge productivity [PDF]
, 2008 This study explores the learning processes that contribute to knowledge productivity: gradual improvement and radical innovation of an organisation’s operating procedures, products, and services, based on the development and application of new knowledge.
Kessels, Joseph W.M. +1 more
core +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source