Results 91 to 100 of about 557,025 (268)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

ANALYSIS OF INNOVATION ACTIVITY OF SLOVAK AND CZECH ENTERPRISES [PDF]

Kvalita Inovácia Prosperita, 2010
European innovation scoreboard is used to monitor and compare the innovation performance of European countries, according to which was the Slovak Republic, together with two other V4 countries, i.e.
EMÍLIA SPIŠÁKOVÁ
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

O valor educativo do desporto: Desafios e dificuldades percebidas por treinadores de crianças e jovens

Motricidade
Este estudo investigou os desafios e dificuldades enfrentadas pelos treinadores ao transmitir valores educativos do desporto e as suas estratégias para lidar com a falta desses valores nos seus jovens atletas.
Rafael Ramos, Ivo Cortinhas, Luís Aguilar, Teresa Fonseca, Helder Miguel Fernandes   +4 more
doaj   +1 more source

LEGAL SUPPORT TO INNOVATIVE ACTIVITIES [PDF]

Экономика региона, 2009
The whole system of economy regulation, all the institutes of economic law, especially those which regulate investment activity should promote innovative activities. The economic policy and legislation that provides it should be stable enough.
openaire   +1 more source

Study of the Impact of Innovation Capacity Factors on the Activation of Company’s Innovation Activity

Economic Alternatives, 2019
The more topical the issues and the importance of innovations get, the higher the interest in theoretical clarification and empirical study of various aspects of the innovation capacity of enterprises. The number of scientific publications in these areas of research is growing.
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Implications of pubertal stage in cardiometabolic risk factors in obese adolescents: a network analysis

BMC Pediatrics
Introduction Despite the existence of numerous studies describing the early stages of sexual maturation in overweight children, there is still a gap in understanding the consequences of obesity at each level of pubertal development and its association ...
Déborah Cristina de Souza Marques, Mileny Caroline Menezes de Freitas, Marilene Ghiraldi de Souza Marques, Luciana Lozza de Moraes Marchiori, Thiago Kenzo Guinoza Lima, Joed Jacinto Ryal, Clarice Maria de Lucena Martins, Jorge Mota, Pablo Valdés-Badilla, Braulio Henrique Magnani Branco   +9 more
doaj   +1 more source